Ti3C2TX MXene nanosheets/α-MnO2 nanorods composite-modi­fied electrode for efficient electrochemical determination of dasatinib

Original scientific paper

Authors

  • Somayeh Tajik NanoBioelectrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran https://orcid.org/0000-0002-1151-5515
  • Razieh Moghimian Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran https://orcid.org/0009-0009-9822-4267
  • Fariba Garkani Nejad Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran https://orcid.org/0000-0002-3919-950X
  • Fatemeh Sharifi Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran https://orcid.org/0000-0003-1711-0540
  • Azadeh Lohrasbi-Nejad Institute of Plant Production (IPP), Afzalipour Research Institute (ARI), Shahid Bahonar University of Kerman, Kerman, Iran https://orcid.org/0000-0003-3269-437X
  • Hadi Beitollahi Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran https://orcid.org/0000-0002-0669-5216

DOI:

https://doi.org/10.5599/admet.3729

Keywords:

Cancer, electrochemical sensor, screen-printed electrode, two-dimensional transition-metal carbides, nanostructured transition-metal oxides

Abstract

Background and purpose: Chemotherapy is a cornerstone of cancer treatment that utilizes one or more cytotoxic agents to inhibit the growth and proliferation of malignant cells. However, the considerable toxicity and dose-dependent side effects of chemotherapeutic drugs underscore the need for their precise and ultrasensitive quantification. Experimental approach: A sensitive, simple, and fast electrochemical method was developed for the determination of dasatinib, utilizing a disposable carbon screen-printed electrode (CSPE) modified with a Ti3C2TX MXene nanosheets (NSs)/α-MnO2 nanorods (NRs) composite. Key results: The utilization of the Ti3C2TX MXene NSs/α-MnO2 NRs composite on the CSPE surface demonstrated outstanding cyclic voltammetric response. This modification significantly increased the peak current for dasatinib oxidation, from 2.8 µA at the bare CSPE to 11.1 µA at the Ti3C2TX MXene NSs/α-MnO2 NRs/SPCE surface. Moreover, the oxidation of dasatinib shifted noticeably toward lower potentials on the modified CSPE surface, indicating faster electron-transfer kinetics. The differential pulse voltammetry method was applied for the quantitative determination of dasatinib, achieving a linear response over the concentration range of 0.01 to 400.0 µM with a detection limit of 0.005 µM. Finally, the method's applicability was evaluated for the determination of dasatinib in the tablet sample. Recovery values in the range of 96.6 to 103.8 % were achieved, showing adequate accuracy. Conclusion: This analytical approach provides an effective tool for analysing pharmaceutical formulations with potential applications in cancer therapy. 

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Published

04-11-2026

Issue

Vol. 14 (2026)

Section

Medicinal chemistry

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Copyright (c) 2026 Somayeh Tajik, Razieh Moghimian, Fariba Garkani Nejad, Fatemeh Sharifi, Azadeh Lohrasbi-Nejad, Hadi Beitollahi

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Ti3C2TX MXene nanosheets/α-MnO2 nanorods composite-modi­fied electrode for efficient electrochemical determination of dasatinib: Original scientific paper. (2026). ADMET and DMPK, 14, Article 3729. https://doi.org/10.5599/admet.3729

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