Y-Co metal-organic framework for sensitive electrochemical determination of doxorubicin hydrochloride: Original scientific article

Somayeh Mir; Niloufar Akbarzadeh Torbati; Vahid  Amani; Somayeh Tajik; Hadi Beitollahi

doi:10.5599/admet.3141

Authors

Somayeh Mir Department of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran https://orcid.org/0009-0007-2394-023X
Niloufar Akbarzadeh Torbati Department of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran https://orcid.org/0000-0002-3614-5899
Vahid Amani Department of Chemistry Education, Farhangian University, P.O. Box 14665-889, Tehran, Iran https://orcid.org/0000-0003-3802-027X
Somayeh Tajik Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran https://orcid.org/0000-0002-1151-5515
Hadi Beitollahi Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran https://orcid.org/0000-0002-0669-5216

DOI:

https://doi.org/10.5599/admet.3141

Keywords:

Pharmaceutical formulations, chemotherapy treatment, electrochemical sensor

Abstract

Background and purpose: Cancer represents a major challenge to public health; therefore, identifying doxorubicin hydrochloride (DOX·HCl) as an important chemotherapy drug holds considerable significance. Experimental approach: An electrochemical sensing strategy was designed for DOX·HCl determination by using Y-Co bimetallic metal-organic framework (Y-Co MOF) modified carbon paste electrode (CPE). The Y-Co-MOF was successfully prepared via the solvothermal method. Key results: Characterizations using field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and energy-dispersive X-ray spectroscopy with elemental mapping images were used to evaluate the morphological features, crystalline structure, functional groups, and elemental composition of the Y-Co-MOF. From cyclic voltammetric studies, well-defined redox peaks of DOX·HCl with improved response peak currents at lower overpotentials were observed on the surface of Y-Co MOF/CPE compared to the unmodified CPE. This indicated that the as-prepared modified CPE has a strong and efficient redox capability toward DOX·HCl. Under the optimized parameters and conditions, the linear response range from differential pulse voltammetry measurements for DOX·HCl were 0.0025 to 100.0 µM, with a low limit of detection of 0.001 µM. Finally, the ability of the designed sensing platform to determine the amounts of DOX·HCl in the injection sample was studied and it has been observed a high and efficient ability with satisfactory values of recovery and relative standard deviation. Conclusion: This analytical approach offers a useful means for the analysis of pharmaceutical formulations, providing potential advantages in cancer therapy.

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