Epirubicin-sensitive detection with a CoWO4/reduced graphene oxide modified screen-printed electrode: Original scientific article

Somayeh Tajik; Razieh Moghimian; Hadi Beitollahi

doi:10.5599/admet.2733

Authors

Somayeh Tajik Research Centre of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran https://orcid.org/0000-0002-1151-5515
Razieh Moghimian Research Centre of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran https://orcid.org/0009-0009-9822-4267
Hadi Beitollahi Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran; https://orcid.org/0000-0002-0669-5216

DOI:

https://doi.org/10.5599/admet.2733

Keywords:

CoWO4/reduced graphene oxide nanocomposite, chemically modified electrode, urine sample, cancer, drug analysis

Abstract

Background and purpose: Because of its antimetabolic and cytotoxic qualities, epirubicin (EP), a crucial chemotherapeutic drug, has been used to treat a number of cancers, including those of the prostate, breast, ovary, stomach, lung, and colon. Experimental approach: In this study, CoWO4/reduced graphene oxide (CoWO₄/rGO) nanocomposite was synthesized and characterized by field emission-scanning electron microscopy and energy-dispersive X-ray spectroscopy. To provide a novel sensing platform for EP determination, a screen-printed electrode (SPE) surface was modified using the as-fabricated CoWO₄/rGO nanocom¬posite. Key results: Using voltammetric techniques, the electrochemical behavior of the CoWO₄/rGO nanocomposite modified SPE (CoWO₄/rGO/SPE) for the EP detection was examined. CoWO₄/rGO significantly reduced the overpotential of EP redox reaction and increased the rate of electron transfer between the electrode and analyte as compared to bare SPE. EP was quantitatively analyzed using differential pulse voltammetry. Conclusions: It was discovered that the linearity range was 0.01 to 190.0 μM. The sensitivity and limit of detection were 0.1529 μA μM^-1 and 0.007 μM, respectively. Additionally, the constructed CoWO₄/rGO/SPE sensor's practical applicability was investigated in pharmaceutical samples with good recovery outcomes.

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