Author guidelines

• Manuscripts for submission
• Figures, Schemes, Sketches and Tables
• Naming, units and designations
• Organizing the Manuscript
• References
• Equations
• Artwork instructions
• Cover letter
• Graphical abstract

Each submission consists of three required items along with several optional ones. The required items are Manuscript, Graphical abstract and Cover letter. Please read below the instructions how to prepare each submission item.

Manuscripts for submission
The manuscript should be uploaded as a single Word.doc .docx or .rtf file. Manuscripts have to be typed in English (consistent standard British or American English is required) with 1.5 line spacing (11 points size of Calibri font; Greek letters from Symbol character set) and in an A4 page format leaving 2.0 cm wide margins. The use of Microsoft Word template is strongly encouraged. Do not insert any graphics (schemes, figures, etc.) into a movable frame which can superimpose the text and make the layout very difficult (must be In „Line with Text“). For Regional specific, nonstandard characters please save documents with "Embed fonts" Word option: Save as ‐> (Tools) ‐> Save Options… ‐> Embed fonts in the text.

Figures, Schemes, Sketches and Tables
Authors are encouraged to prepare illustrations in color. Graphic objects and Tables must be numbered, each consecutively by Arabic numbers with precise captions and Table titles supplied. They should be inserted into the main text. All table columns should have a heading cell which explains clearly the data filled in. Footnotes to table contents, in font size of 10, are to be indicated consequently by superscripted small letters. Tables should be prepared by MS Word “Insert table” tools. The position of Table columns must not be formatted using the space tab. Table rows must not be formatted using carriage returns (enter key). Tables must not be incorporated as graphic objects.
All Illustrations should be prepared according to artwork instructions.

Naming, units and designations
IUPAC recommendations for the naming of compounds and physical quantities should be strictly followed. Avoid the use of the same abbreviation for different quantities. SI units, or other permissible units, should be used. The designation of physical quantities must be in italic throughout the text (including figures, tables and equations), whereas the units are in upright letters. They should be in Calibri font. In graphs and tables, the presentation of the numeric values of the variables should be mathematically correct (example: j / A m^-2, m / kg, T / K…). However, if the full name of a physical quantity is unavoidable, it should be given in upright letters and separated from the unit by a comma (example: Pressure, kPa; Temperature, K; Current density, mA cm^-2…). Any other designations are not acceptable. If the quantity presented at the graph axis or in the table heading requires additional explanations, this should be given in the caption or table title or footnote.
Latin words should be typed in italic, as for example: i.e. in vivo, etc.

Organizing the Manuscript
First page
It should contain clear and concise Title in bold letters (limited to 10 words). The use of abbreviations, symbols and formulae has to be avoided.

• Authors’ names with full first name and initials of further names separated by a space followed by surname. If the authors are from different institutions, the author’s affiliation should be indicated by an Arabic number placed in superscript after the surname. Use the asterisk(s) to denote the corresponding author(s).
• Affiliations should be written in italic with preceding Arabic number if many. The e-mail address(es) of the author(s) should be given after the affiliation(s).
• Abstract: An abstract in at last 200-words pointing the brief and concise highlights of the article, should be supplied.
• Keywords: Up to 6 keywords separated by semicolon should be given. Do not use words appearing in the manuscript title.
• Running title: A one line (maximum five words) short title should be provided.

Main text
The main text should have the form: Introduction, Experimental, Results and discussions and Conclusions.
Subsection headings should be given in separate lines and typed in italic small letters.

• Introduction should include the aim of the research and a concise description of the topic with appropriate references to related studies.
• Experimental section should give the clear and reproducible details about experimental work and methods applied as well as details of the instruments used.
• Results and discussion should include the results obtained and their significance discussed and compared to relevant literature data. Separating Results and Discussion into the separate subsecions is acceptable.
• Conclusion section should briefly summarize the main outcomes of the paper and future perspective of the research.

Conflict of interest
Statement of the conflict of interest must explicitly declare whether such conflict does or does not exist.

Acknowledgements

References
References should be numbered sequentially as they appear in the text. Endonte reference formatting style is available for download. Mendeley users could use this style for reference formatting.
Reference numbers should be placed in square brackets [ ] and placed before the punctuation. In the reference list, they should be in normal position following the corresponding number in square brackets and ended by a full stop. Reference entry must not be formatted using Carriage returns (enter key) or multiple space key. The formatting of references to published work should be as follows:

• Journals: [1] A.B. Surname1, C.D. Surname2. Article title. Full Journal Title Vol (Year) first‐last page number. https://doi.org/doi.*
• Books: [2] A.B. Surname1, C.D. Surname2, Name of Book, Publisher, City, Country, Year, p. 100. https://dx.doi.org/doi.*
• Compilations: [3] A.B. Surname1, C.D. Surname2, Name of Chapter, in Name of Compilation, A.B. Editor1, C.D. Editor2, Ed(s)., Publisher, City, Country, Year, p. 100. https://dx.doi.org/doi.*
• Proceedings: [4] A.B. Surname1, C.D. Surname2, Name of the Conference or Symposium, Title of the Proceeding, Place of the Conference, Country, Year, p. 100 (or abstract No.).
• Websites: [5] Title of the website, URL in full (date accessed).
• Patents: [6] A.B. Inventor1, C.D. Inventor2, (Holder), Country Code and patent number (registration year).
• Standards: [7] EN ISO 250: Name of the Standard (Year).

Endnote reference formatting style could be downloaded from here. Mendeley users could use this style for reference formatting. The references found on PubMed Database could be automatically formatted to ADMET and DMPK reference style using PMID2Cite, web-based generator.

The original journal title is to be retained in the case of publications published in any language other than English (please denote the language in parenthesis after the reference). Titles of publications in non‐Latin alphabets should be transliterated.

Mathematical and chemical equations must be numbered, Arabic numbers, consecutively in parenthesis at the end of the line. All equations should be embedded in the text and prepared with the aid of the WORD Equation editor or MathType.

Latin words, as well as the names of species, should be in italic, as for example: i.e., e.g., in vivo, ibid, Calendula officinalis L., etc. The branching of the organic compound should also be indicated in italic, for example, n-butanol, tert-butanol, etc.

Artwork instructions
ADEMT and DMPK accepts only TIF, JPEG, GIF or PNG formats of illustrations; those edited within MS files (Word, PowerPoint, Excel, Visio) ARE NOT acceptable. Scanned instrument data sheets are not acceptable too. Authors are fully responsible for the quality of their submitted artwork. Generally, all common artwork and graphic creation software are capable of saving files in mentioned formats. This 'option' can normally be found under the 'Save As...' or 'Export...' commands in the 'File' menu. Preferrable formats are .jpg, .tif, .png.
Resolution
When supplying graphic files, please ensure that the files are supplied in the correct resolution:

1. Line artwork: minimum of 1000 dpi
2. RGB image: minimum of 300 dpi
3. Greyscale image: minimum of 300 dpi
4. Combined artwork (line/greyscale/RGB): minimum of 300 dpi

Sizing of Artwork

• ADMET and DMPK aspires to have a uniform look for all artwork contained in a single article. Hence, it is important to be aware of the style of the journal.
• As a general rule, the lettering on artwork should have a finished, printed size of 11 pt for normal text and no smaller than 7 pt for subscript and superscript characters. Smaller lettering will yield a text that is barely legible. This is a rule‐of‐thumb rather than a strict rule. There are instances where other factors in the artwork, (for example, tints and shadings) dictate a finished size of perhaps 10 pt. Lines should be of at least 1.5 pt thickness.
• When deciding on the size of a line art graphic, in addition to the lettering, there are several other factors to address. These all have an effect on the reproducibility/readability of the final artwork. Every relevant detail in the illustration, the graph symbols (squares, triangles, circles, etc.) and a key to the diagram (to explain the graph symbols used) must be discernible.
• The sizing of halftones (photographs and micrographs) normally causes more problems than line art. It is sometimes difficult to know what an author is trying to emphasize on a photograph, so you can help us by identifying the important parts of the image, perhaps by highlighting the relevant areas on it. The best advice that can be given is not to over‐reduce halftones. Attention should also be paid to magnification factors or scale bars on the artwork and they should be compared with the details inside. If a set of artwork contains more than one halftone, again please ensure that there is consistency in size between similar diagrams.

General sizing of illustrations which can be used for the ADMET and DMPK:

• Small figure size ‐ 60 mm width
• Medium figure size ‐ 90 mm width
• Large figure size ‐ 120 mm width

Cover letter
Cover letter to Editor must be supplied along with the manuscript. Cover letter explains briefly the scientific outcome of the manuscript and the importance of the reported results. Authors are required to provide a statement about the submission describing how the manuscript fits to the journal content. It has to state clearly that the manuscript concerns original unpublished results and that the manuscript is not simultaneously in publishing procedure of some other scientific journal. In addition, three potential referees must be stated in the letter.

Graphical abstract
Graphical abstract is a one-image file containing the main depiction of the authors work and/or conclusion and must be supplied along with the manuscript. It must enable readers to quickly gain the main message of the paper and to encourage browsing, help readers identify which papers are most relevant to their research interests.

Authors must provide an image that clearly represents the research described in the paper. The most relevant figure from the work, which summarizes the content, can also be submitted. The image should be submitted as a separate file in Step 2.

Specifications: The graphical abstract should have a clear start and end, reading from top to bottom or left to right. Please omit unnecessary distractions as much as possible.

• Image size: minimum of 800x450 pixels (WxH) and a minimum resolution of 300 dpi. If a larger image is sent, then please use the same ratio: 16 wide x 9 high. Please note that your image will be scaled proportionally to fit in the available window in TOC; a 200x112 pixel rectangle. Please be sure that the quality of an image cannot be increased by changing the resolution from lower to higher, but only by rescanning or exporting the image with a higher resolution, which can be set in usual "settings" option.
• Font: Please use Calibri and Symbol font with a large enough font size, so it is readable even from the image of a smaller size (200 x 112 px) in TOC.
• File type: JPG and PNG only.

No additional text, outline or synopsis should be included. Please do not use white space or any heading within the image.

The manuscripts not prepared according to the instructions will be returned to authors for the correction.