Author guidelines

• Manuscripts for submission
• Figures, Schemes, Sketches and Tables
• Naming, units and designations
• Organizing the Manuscript
• References
• Statements and Declarations
• Equations
• Artwork instructions
• Supplementary material
• Research data
• Cover letter
• Graphical abstract

Each submission consists of three required items along with several optional ones. The required items are Manuscript, Graphical abstract and Cover letter. Authors are strongly encouraged to supply also Supplementary material as well as the Research data. Please read below the instructions how to prepare each submission item.

Manuscripts for submission
The manuscript should be uploaded as a single Word.doc .docx or .rtf file. Manuscripts have to be typed in English (consistent standard British or American English is required) with 1.5 line spacing (11 points size of Calibri font; Greek letters from Symbol character set) and in an A4 page format leaving 2.0 cm wide margins. The use of Microsoft Word template is madatory. Do not insert any graphics (schemes, figures, etc.) into a movable frame which can superimpose the text and make the layout very difficult (must be In „Line with Text“). For Regional specific, nonstandard characters please save documents with "Embed fonts" Word option: Save as ‐> (Tools) ‐> Save Options… ‐> Embed fonts in the text.

Figures, Schemes, Sketches and Tables
Authors are encouraged to prepare illustrations in color. Graphic objects and Tables must be numbered, each consecutively by Arabic numbers with precise captions and Table titles supplied. They should be inserted into the main text. All table columns should have a heading cell which explains clearly the data filled in. Footnotes to table contents, in font size of 10, are to be indicated consequently by superscripted small letters. Tables should be prepared by MS Word “Insert table” tools. The position of Table columns must not be formatted using the space tab. Table rows must not be formatted using carriage returns (enter key). Tables must not be incorporated as graphic objects.
All Illustrations should be prepared according to artwork instructions.

Naming, units and designations
IUPAC recommendations for the naming of compounds and physical quantities should be strictly followed. Avoid the use of the same abbreviation for different quantities. SI units, or other permissible units, should be used. The designation of physical quantities must be in italic throughout the text (including figures, tables and equations), whereas the units are in upright letters. They should be in Calibri font. In graphs and tables, the presentation of the numeric values of the variables should be mathematically correct (example: j / A m^-2, m / kg, T / K…). However, if the full name of a physical quantity is unavoidable, it should be given in upright letters and separated from the unit by a comma (example: Pressure, kPa; Temperature, K; Current density, mA cm^-2…). Any other designations are not acceptable. If the quantity presented at the graph axis or in the table heading requires additional explanations, this should be given in the caption or table title or footnote.
Latin words should be typed in italic, as for example: i.e. in vivo, etc.

Organizing the Manuscript
First page
It should contain clear and concise Title in bold letters (limited to 10 words). The use of abbreviations, symbols and formulae has to be avoided.

• Authors’ names with full first name and initials of further names separated by a space followed by surname. If the authors are from different institutions, the author’s affiliation should be indicated by an Arabic number placed in superscript after the surname. Use the asterisk(s) to denote the corresponding author(s).
• Affiliations should be written in italic with preceding Arabic number if many. The e-mail address(es) of the author(s) should be given after the affiliation(s).
• Abstract: The abstract must be structured, under the following sub-headings, up to 250 words: (i) Background and Purpose - This must indicate why the study was performed and what scientific questions that the study was intended to answer, (ii) Experimental Approach - This should outline what experimental methods were used. Details on media, buffers, drug concentrations, time points, statistics, etc., could be omitted unless they are important in relation to the question that was addressed, (iii) Key Results - The main results relevant to the question addressed should be summarized without quantitative and detailed elaboration, (iv) Conclusion - Summarize the main implications that follow from the results, while mentioning important shortcomings, if any. This paragraph must clearly spell out in what ways the work has advanced knowledge in the field.
• Keywords: Up to 6 keywords separated by semicolon should be given. Do not use words appearing in the manuscript title.
• Running title: A one line (maximum five words) short title should be provided.

Main text
The main text should have the form: Introduction, Material and methods, Results, Discussions, Conclusions, References, Figures, Legends.
Subsection headings should be given in separate lines and typed in italic small letters.

• Introduction should include the aim of the research and a concise description of the topic with appropriate references to related studies.
• Experimental section should give the clear and reproducible details about experimental work and methods applied as well as details of the instruments used.
• Results and discussion should include the results obtained and their significance discussed and compared to relevant literature data. Separating Results and Discussion into the separate subsecions is acceptable.
• Conclusion section should briefly summarize the main outcomes of the paper and future perspective of the research.

References
References should be numbered sequentially as they appear in the text. Endonte reference formatting style is available for download. Mendeley users could use this style for reference formatting.
Reference numbers should be placed in square brackets [ ] and placed before the punctuation. In the reference list, they should be in normal position following the corresponding number in square brackets and ended by a full stop. Reference entry must not be formatted using Carriage returns (enter key) or multiple space key. The formatting of references to published work should be as follows:

• Journals: [1] A.B. Surname1, C.D. Surname2. Article title. Full Journal Title Vol (Year) first‐last page number. https://doi.org/doi.*
• Books: [2] A.B. Surname1, C.D. Surname2, Name of Book, Publisher, City, Country, Year, p. 100. https://dx.doi.org/doi.*
• Compilations: [3] A.B. Surname1, C.D. Surname2, Name of Chapter, in Name of Compilation, A.B. Editor1, C.D. Editor2, Ed(s)., Publisher, City, Country, Year, p. 100. https://dx.doi.org/doi.*
• Proceedings: [4] A.B. Surname1, C.D. Surname2, Name of the Conference or Symposium, Title of the Proceeding, Place of the Conference, Country, Year, p. 100 (or abstract No.).
• Websites: [5] Title of the website, URL in full (date accessed).
• Patents: [6] A.B. Inventor1, C.D. Inventor2, (Holder), Country Code and patent number (registration year).
• Standards: [7] EN ISO 250: Name of the Standard (Year).

Endnote reference formatting style could be downloaded from here. Mendeley users could use this style for reference formatting. The references found on PubMed Database could be automatically formatted to ADMET and DMPK reference style using PMID2Cite, web-based generator.

Statements and declarations
The statements described below are mandatory. Submissions that do not include required statements will be returned as incomplete submission. If the particular statements are not applicable to the study, just enter NA.

• Acknowledgements: Acknowledge the support and help received from others which are not qualified as co-authors. Equipment usage, sample supply received from other party may also mention in this section. Funding: Please describe any sources of funding that have supported the work. The statement should include details of any grants received (please give the name of the funding agency and grant number).
• Conflicts of interest: Authors are required to disclose financial or non-financial interests that are directly or indirectly related to the work submitted for publication.
• Author Contributions: Authors are required to include a statement that specifies the contribution of every author to the research and preparation of the manuscript. Example statement: “All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Author A and Author B. Author C supervised all phases of the study, including the manuscript writing. All authors read and approved the final manuscript.”
• Data availability: All original research papers must include a Data Availability Statement. Data Availability Statements should provide information on where data supporting the results reported in the article can be found. Statements should include, where applicable, hyperlinks to publicly archived datasets analyzed or generated during the study. When it is not possible to share research data publicly, data availability should still be stated in the manuscript along with any conditions for access. Example statement: “The datasets generated during and/or analyzed during the current study are not publicly available due to [state reason(s)] but are available from the corresponding author on reasonable request.”
• Ethics approval and consent to participate: For research involving human or animal subjects authors should include a statement that confirms that the study was approved (or granted exemption) by the appropriate institutional and/or national research ethics committee (including the name of the ethics committee and reference number, if available). Example statements: “This study was performed in accordance with the principles of the Declaration of Helsinki and was approved the Ethics Committee of University XXX (Date.../No....).”, “All animal study protocols were approved by the Ethics Committee of University XXX (Date.../No....)”.
• Consent to participate: For all research involving human subjects, freely-given, informed consent to participate in the study must be obtained from participants (or their parent or legal guardian in the case of children under 16) and a statement to this effect should appear in the manuscript. Example statement: “Informed consent was obtained from all individual participants included in the study.”
• Consent to publish: Individuals may consent to participate in a study, but object to having their data published in a journal article. If your manuscript contains any individual person’s data in any form (including any individual details, images or videos), consent for publication must be obtained from that person, or in the case of children, their parent or legal guardian. This is in particular applicable to case studies. A statement confirming that consent to publish has been received from all participants should appear in the manuscript. Example statement: “The authors confirm that human research participants provided informed consent for publication of the XX in Table(s)/Figure(s) YY”

The original journal title is to be retained in the case of publications published in any language other than English (please denote the language in parenthesis after the reference). Titles of publications in non‐Latin alphabets should be transliterated.

Mathematical and chemical equations must be numbered, Arabic numbers, consecutively in parenthesis at the end of the line. All equations should be embedded in the text and prepared with the aid of the WORD Equation editor or MathType.

Latin words, as well as the names of species, should be in italic, as for example: i.e., e.g., in vivo, ibid, Calendula officinalis L., etc. The branching of the organic compound should also be indicated in italic, for example, n-butanol, tert-butanol, etc.

Artwork instructions
ADEMT and DMPK accepts only TIF, JPEG, GIF or PNG formats of illustrations; those edited within MS files (Word, PowerPoint, Excel, Visio) ARE NOT acceptable. Scanned instrument data sheets are not acceptable too. Authors are fully responsible for the quality of their submitted artwork. Generally, all common artwork and graphic creation software are capable of saving files in mentioned formats. This 'option' can normally be found under the 'Save As...' or 'Export...' commands in the 'File' menu. Preferrable formats are .jpg, .tif, .png.
Resolution
When supplying graphic files, please ensure that the files are supplied in the correct resolution:

1. Line artwork: minimum of 1000 dpi
2. RGB image: minimum of 300 dpi
3. Greyscale image: minimum of 300 dpi
4. Combined artwork (line/greyscale/RGB): minimum of 300 dpi

Sizing of Artwork

• ADMET and DMPK aspires to have a uniform look for all artwork contained in a single article. Hence, it is important to be aware of the style of the journal.
• As a general rule, the lettering on artwork should have a finished, printed size of 11 pt for normal text and no smaller than 7 pt for subscript and superscript characters. Smaller lettering will yield a text that is barely legible. This is a rule‐of‐thumb rather than a strict rule. There are instances where other factors in the artwork, (for example, tints and shadings) dictate a finished size of perhaps 10 pt. Lines should be of at least 1.5 pt thickness.
• When deciding on the size of a line art graphic, in addition to the lettering, there are several other factors to address. These all have an effect on the reproducibility/readability of the final artwork. Every relevant detail in the illustration, the graph symbols (squares, triangles, circles, etc.) and a key to the diagram (to explain the graph symbols used) must be discernible.
• The sizing of halftones (photographs and micrographs) normally causes more problems than line art. It is sometimes difficult to know what an author is trying to emphasize on a photograph, so you can help us by identifying the important parts of the image, perhaps by highlighting the relevant areas on it. The best advice that can be given is not to over‐reduce halftones. Attention should also be paid to magnification factors or scale bars on the artwork and they should be compared with the details inside. If a set of artwork contains more than one halftone, again please ensure that there is consistency in size between similar diagrams.

General sizing of illustrations which can be used for the ADMET and DMPK:

• Small figure size ‐ 60 mm width
• Medium figure size ‐ 90 mm width
• Large figure size ‐ 120 mm width

Supplementary material
Supplementary material such as applications, images and sound clips, can be published with your article to enhance it. Submitted supplementary items are published exactly as they are received (Excel or PowerPoint files will appear as such online). Please submit your material together with the article and supply a concise, descriptive caption for each supplementary file. If you wish to make changes to supplementary material before the article is formally published, please make sure to provide an updated file.  Do not annotate any corrections on a previous version. Please switch off the 'Track Changes' option in Microsoft Office files as these will appear in the published version.

Research data
ADMET and DMPK encourages authors to share data that supports their research publication where appropriate. Research data here refers to the results of observations or experimentation that validate research findings. To facilitate reproducibility and data reuse, this journal also encourages authors to share software, code, models, algorithms, protocols, methods and other useful materials related to the project.

Cover letter
Cover letter to Editor must be supplied along with the manuscript. Cover letter explains briefly the scientific outcome of the manuscript and the importance of the reported results. Authors are required to provide a statement about the submission describing how the manuscript fits to the journal content. It has to state clearly that the manuscript concerns original unpublished results and that the manuscript is not simultaneously in publishing procedure of some other scientific journal. In addition, three potential referees must be stated in the letter.

Graphical abstract
Graphical abstract is a one-image file containing the main depiction of the authors work and/or conclusion and must be supplied along with the manuscript. It must enable readers to quickly gain the main message of the paper and to encourage browsing, help readers identify which papers are most relevant to their research interests.

Authors must provide an image that clearly represents the research described in the paper. The most relevant figure from the work, which summarizes the content, can also be submitted. The image should be submitted as a separate file in Step 2.

Specifications: The graphical abstract should have a clear start and end, reading from top to bottom or left to right. Please omit unnecessary distractions as much as possible.

• Image size: minimum of 800x450 pixels (WxH) and a minimum resolution of 300 dpi. If a larger image is sent, then please use the same ratio: 16 wide x 9 high. Please note that your image will be scaled proportionally to fit in the available window in TOC; a 200x112 pixel rectangle. Please be sure that the quality of an image cannot be increased by changing the resolution from lower to higher, but only by rescanning or exporting the image with a higher resolution, which can be set in usual "settings" option.
• Font: Please use Calibri and Symbol font with a large enough font size, so it is readable even from the image of a smaller size (200 x 112 px) in TOC.
• File type: JPG and PNG only.

No additional text, outline or synopsis should be included. Please do not use white space or any heading within the image.

The manuscripts not prepared according to the instructions will be returned to authors for the correction.