Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite: A promising voltammetric platform for sensitive determination of doxorubicin

Original scientific paper

Authors

  • Tahereh Kondori Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran https://orcid.org/0009-0008-2028-2478
  • Niloufar Akbarzadeh-T Department of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran https://orcid.org/0000-0002-3614-5899
  • Somayeh Tajik Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran https://orcid.org/0000-0002-1151-5515
  • Hadi Beitollahi Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran https://orcid.org/0000-0002-0669-5216

DOI:

https://doi.org/10.5599/admet.3384

Keywords:

Cancer, differential pulse voltammetry, voltammetric sensor, real sample, synergistic interaction

Abstract

Background and purpose: Doxorubicin (DOX) serves as an anthracycline-based chemotherapy drug to treat multiple types of cancers and sarcomas, which include lung, breast, bladder, leukaemia, liver, head and neck cancers. Experimental approach: The electroanalysis of the trace level of DOX in this study was conducted using a Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite (Zn-Ni MOF NSs@GO) after the modification of a screen-printed carbon electrode (Zn-Ni MOF NSs@GO/SPCE). Using chronoampero­metry, cyclic voltammetry and differential pulse voltammetry, the electrochemical characteristics of the sensor as constructed for DOX measurement were examined. Key results: Consequently, the composite sensor demonstrated exceptional electrocatalytic performance in oxidizing DOX within a concentration range of 0.004 to 190.0 μM, with a detection limit of 0.001 μM. It was found that the Zn-Ni MOF NSs@GO/SPCE was effective at determining DOX in real samples, with good recovery values in the 97.1 to 102.0 % range. Conclusion: The designed sensor with cost-effective and good performance could be valuable for therapeutic drug monitoring and clinical diagnostics.

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Published

08-07-2026

Issue

Vol. 14 (2026)

Section

Pharmaceutical and biomedical analysis

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Copyright (c) 2026 Tahereh Kondori, Niloufar Akbarzadeh-T, Somayeh Tajik, Hadi Beitollahi

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite: A promising voltammetric platform for sensitive determination of doxorubicin: Original scientific paper. (2026). ADMET and DMPK, 14, Article 3384. https://doi.org/10.5599/admet.3384

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