ZnO-modified carbon paste electrode for electrochemical sensing of dopamine in the presence of tyrosine: Original scientific article

Ali Obaid Imarah; Nada  Hasan; Mustafa G.   Alabbasi

doi:10.5599/admet.3010

Authors

Ali Obaid Imarah Department of Chemical Engineering, College of Engineering, University of Babylon, Babylon Iraq https://orcid.org/0000-0003-0450-2588
Nada Hasan Department of Basic Science, College of Dentistry, Al-Mustaqbal University, Babylon, Hillah, 51001, Iraq https://orcid.org/0000-0002-6878-9541
Mustafa G. Alabbasi Department of Pharmacology and Toxicology, College of Pharmacy, University of Alkafeel, Iraq https://orcid.org/0000-0001-7166-0151

DOI:

https://doi.org/10.5599/admet.3010

Keywords:

ZnO nanoparticles, voltammetry, Alzheimer's disease, Parkinson's disease, chronoamperometry

Abstract

Background and purpose: Dopamine, 3,4-dihydroxyphenylalanine, functions as a catecholamine neurotransmitter in the brain, sending messages to other neurons to regulate information transmission to other areas of the brain, govern movement, and alter brain activity. Tyrosine undergoes an enzymatic process in the pharmaceutical industry to produce dopamine. Thus, it is crucial to measure both tyrosine and dopamine in bodily fluids simultaneously. Experimental approach: In this work, we demonstrate the production of ZnO nanoparticles using a straightforward solvothermal technique. A straightforward, quick, and sensitive electrochemical sensing platform for dopamine detection was then created using the produced ZnO nanoparticles. Key results: Cyclic voltammetry comparison revealed that the ZnO/carbon paste electrode considerably enhanced the dopamine oxidation process compared to the unmodified carbon paste electrode (CPE). With a low detection limit of 0.003 μM, the ZnO/CPE sensor's linear response for voltammetric dopamine determination was found to be between 0.01 and 480.0 μM. Conclusion: The modified CPE effectively demonstrates its great accuracy in tyrosine-induced dopamine detection.

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