A new method for measuring dopamine in the presence of uric acid employing a carbon paste electrode modified with the  UiO-66 metal organic framework-graphene oxide nanocomposite: Original scientific article

Azhar Hameed Gatea; Aseer Shakir Ajel; Raed Muslim Muhibes

doi:10.5599/admet.2593

Authors

Azhar Hameed Gatea Department of Pathological Analytics Science, College of Applied Medical Science, Shatrah University, Thi-Qar, 64001 Iraq https://orcid.org/0000-0002-4803-5494
Aseer Shakir Ajel Department of Pathological Analytics Science, College of Applied Medical Science, Shatrah University, Thi-Qar, 64001, Iraq https://orcid.org/0009-0008-9280-8731
Raed Muslim Muhibes Department of Biochemistry, College of Medicine Misan University, Iraq https://orcid.org/0000-0002-4835-0873

DOI:

https://doi.org/10.5599/admet.2593

Keywords:

Voltammetry, chemically modified electrodes, real sample analysis, electrochemical sensor

Abstract

Background and purpose: Dopamine has an impact on the cardiovascular, endocrine, renal, and central neurological systems. Electrochemical techniques are becoming more and more popular among researchers as a way to assess dopamine and uric acid levels. Experimental approach: Using electrochemical techniques, a new Universitet i Oslo MOF (UiO-66)-graphene oxide nanocomposite-modified carbon paste electrode was created to investigate the electrooxidation of uric acid and dopamine as well as their combinations. At the redesigned electrode, uric acid and dopamine were detected concurrently in a very sensitive way using differential pulse voltammetry (DPV). Key results: Dopamine DPV peak currents increase in a linear fashion at doses between 0.05 and 600.0 µM. Conclusion: Uric acid and dopamine levels in urine and dopamine injection samples may be determined with the help of the proposed sensor, which is reasonably priced and performs well.

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