CuFe2O4 nanoparticles-based electrochemical sensor for sensitive determination of the anticancer drug 5-fluorouracil

Peyman Mohammadzadeh Jahani; Maedeh Jafari; Farhad  Nazari Ravari

doi:10.5599/admet.1691

Authors

Peyman Mohammadzadeh Jahani School of Medicine, Bam University of Medical Sciences, Bam, Iran
Maedeh Jafari Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Farhad Nazari Ravari Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran https://orcid.org/0000-0003-3583-1640

DOI:

https://doi.org/10.5599/admet.1691

Keywords:

Modified electrode, 5-fluorouracil, CuFe2O4, nanoparticles, voltammetriy, electrochemical sensor, SPE

CuFe2O4 nanoparticles-based electrochemical sensor

Abstract

A fast and facile electrochemical sensor for the detection of an important anticancer drug, 5-fluorouracil, is fabricated using CuFe₂O₄ nanoparticles modified screen printed graphite electrode (CuFe₂O₄ NPs/SPGE). The electrochemical activity of the modified electrode was characterized by chronoamperometry, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) and linear sweep voltammetry (LSV) experiments. The CuFe₂O₄ NPs improved the electrochemical properties of the electrodes and enhanced their electroanalytical performance. Electrochemical measurements using differential pulse voltammetry showed a wide linear relationship between 5-fluorouracil concentration and peak height within the range 0.1 to 270.0 µM with a low detection limit (0.03 µM). Further, the sensor was testified with a urine sample and 5-fluorouracil injection sample, and the observed remarkable recovery results replicate its practical applicability.

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