The interactions of model cationic drug with newly synthesized starch derivatives

Justyna Kobryń; Tomasz Zięba; Magdalena Rzepczyńska; Witold Musial

doi:10.5599/admet.1950

Authors

Justyna Kobryń Department of Physical Chemistry and Biophysics, Wrocław Medical University, Borowska 211A, 50-556 Wrocław, Poland https://orcid.org/0000-0002-5241-8906
Tomasz Zięba Department of Food Storage and Technology, Faculty of Biotechnology and Food Science, Wroclaw, University of Environmental and Life Sciences, Chełmońskiego 37, 51-630 Wrocław, Poland https://orcid.org/0000-0002-2791-342X
Magdalena Rzepczyńska Department of Physical Chemistry and Biophysics, Wrocław Medical University, Borowska 211A, 50-556 Wrocław, Poland https://orcid.org/0009-0006-0686-3810
Witold Musial Department of Physical Chemistry and Biophysics, Wrocław Medical University, Borowska 211A, 50-556 Wrocław, Poland https://orcid.org/0000-0001-5695-5998

DOI:

https://doi.org/10.5599/admet.1950

Keywords:

adsorption, interaction, methylene blue, potato starch

Abstract

Background and purpose: The aim of the work was to compare the interactions of three newly synthesized non-toxic starch derivatives, with varied anionic and non-ionic functional groups with methylene blue (MB) as a model cationic drug, and selection of starch derivative with highest affinity to the MB. Experimental approach: The native potato starch (SN), modified via acetylation (SM1), esterification and crosslinking (SM2) and crosslinking (SM3), was evaluated in MB adsorption studies and assessed by FTIR, PXRD, and DSC. Key results: The adsorption of MB on SM2 and SM3 matched the BET isotherm model, which confirmed physisorption on the low-porous surface. In the case of SM1, adsorption took place via electrostatic attraction between the heterogeneous adsorbent surface and the adsorbate, as demonstrated by the Freundlich plot. The FTIR confirmed vibrations assigned to N=C stretching bonds at 1600 cm^-1 in the case of MB adsorbed on the SN and SM2. The most intense PXRD peaks belonged to SN and the least to SM2. In the DSC study, the thermal stability via ΔT was assessed, with SM2 of lowest ΔT value (179.8 °C). Conclusion: SM2 presented the best adsorption capacity, followed by SM3 and the weakest SM1. The interactions were confirmed in the adsorption studies and may reflect applications of the modified starches as drug carriers. In the FTIR study, a probable interaction between the OH^- groups of SM2 and N⁺ of MB was revealed. The most amorphous structure was shown for SM2, which was correlated with the lowest thermal stability provided by the DSC study.

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