Cyclic voltammetry: A simple method for determining contents of total and free iron ions in sodium ferric gluconate complex

Authors

  • Hong Liu College of Pharmaceutical Sciences, Southwest University, Chongqing
  • Qiao Yu College of Pharmaceutical Sciences, Southwest University, Chongqing
  • Yixuan Ma Affiliated Hospital of Qinghai University
  • Baoyu Liu College of Pharmaceutical Sciences, Southwest University, Chongqing
  • Hongchun Pan College of Pharmaceutical Sciences, Southwest University, Chongqing

DOI:

https://doi.org/10.5599/jese.749

Keywords:

Iron content, free iron ions content, iron supplements

Abstract

Sodium ferric gluconate complex (SFGC) is the third generation of iron supplement of polysaccharide iron (III) complex (PIC). For evaluation of technological level and application value of the prepared SFGC, it would be of great significance to determine the iron content in SFGC in a simple but effective way. This paper introduces the cyclic voltammetry (CV) method for determination of iron content in SFGC. Under established optimal experimental conditions, the content of free iron ions can be directly scanned and calculated, while the total iron content can also be determined by completely acidifying SFGC into Fe3+ ions. After optimizing and screening, the optimal scanning conditions are determined as pH 3 and 0.05 V/s of the scanning rate. Prior CV measurements, 0.4 V of the enrichment potential, and 3 min of the enrichment time are found optimal. It has also been verified that CO32- ions present in the solution show little interference in the system within the experimental range of investigation. The contents of free Fe3+, Fe2+ ions and the total iron determined after acid-hydrolysis of SFGC can be accurately calculated according to the corresponding linear relationships between peak currents and iron concentrations. In this paper, the repeatability and accuracy of the method are verified, and its feasibility as a convenient and effective method to determine the iron supplements is confirmed.

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References

X. L. Zhan, F. S. Wang, J. R. Wang, J. Wang, Medical Journal of Qilu 5 (2008) 467-468.

T. S. Koskenkorva-Frank, G. Weiss, W. H. Koppenol, S. Burckhardt, Free Radical Biology and Medicine 65 (2013) 1174-1194.

Z. Yang, H. J. Luo, Foreign Medical Sciences (Section of Hygiene) 2 (2006) 90-93.

M. Kowalczyk, M. Banach, J. Rysz, Journal of Nephrology 24 (2011) 717-722.

C. N. Tang, Anhui Chemical Industry 38 (2016) 1-3.

T. Mitsuoka, Bioscience of Microbiota, Food and Health 33 (2014) 117-128.

K. Mao, Y. X. Ma, H. C. Pan, H. Liu, Chinese Journal of New Drugs 24 (2015) 659-663.

Y. X. Ma, K. Mao, T. Mo, H. C. Pan, H. Liu, Food Science 37 (2016) 64-70.

Y. X. Ma, W. T. Wang, J. J. Wu, H. C. Pan, H. Liu, Food Science 37 (2016) 46-51.

Y. X. Ma, M. Wang, D. Li, H. C. Pan, H. Liu, Food Science and Technology Research, 22(5) (2016) 639-646.

Y. Li, C. X. Wang, Y. Shang, S. Z. Shang, J. W. Guo, Metallurgical Analysis 31 (2011) 72-75.

S. Khan, R. Dashora, A. K. Goswami, D. N. Purohit, Reviews in Analytical Chemistry 23 (2004) 1-74.

H. J. Hu, Y. Tang, H. S. Ying, M. H. Wang, P. Y. Wan, X. J. Yang, Talanta 125 (2014) 425 -431.

C. D. Stalikas, A. Ch. Pappas, M. I. Karayannis, P. G. Veltsistas, Microchimica Acta 142 (2003) 43-48.

J. Bok-Badura, A. Jakobik-Kolon, M. Turek, S. Boncel, K. Karon, RSC Advances 5 (2015) 101634-101640.

A. M. Pisoschi, C. Cimpeanu, G. Predoi, Open Chemistry 13 (2015) 824-856.

M. M. Ghoneim, H. S. El-Desoky, M. M. Abdel-Galeil, Bioelectrochemistry 81 (2011) 65-73.

K. S. Ahn, B. K. Kim, W. Y. Lee, Electrochemistry Communications 58 (2015) 69-72.

J. J. Wu, W. T. Wang, M. Wang, H. Liu, HC. Pan, International Journal of Electrochemical Science 11 (2016) 5165-5179.

D. D. Kong, W. J. Kong, Z. H. Khan, P. Y. Wan, Y. M. Chen, M. H. Yang, Fuel 182 (2016) 266-271.

B. G. Shilpashree, S. Arora, V. Sharma, A. K. Singh, Innovative Food Science & Emerging Technologies 32 (2015) 165-171.

P. C. Pandey, D. Panday, Journal of Electroanalytical Chemistry 763 (2016) 63-70.

E. S. Oliveira, D. R. Gramacho, C. D. Silva, F. Silveira, J. Z. Santos, Z.N. Rocha, Journal of Molecular Catalysis A: Chemical 422 (2016) 198-206.

Z. S. Zhang, X. M. Wang, Z. P. Han, L. Yin, M. X. Zhao, S. C. Yu, Bioorganic & Medicinal Chemistry Letters 22 (2012) 489-492.

A. M. Beltagi, O. M. Abdallah, M. M. Ghoneim, Talanta 74 (2008) 851-859.

Z. K. Xie, L. H. Wei, Q. Yang, M. Yang, H. C Pan, H. Liu, Iranian Journal of Pharmaceutical Research 15 (2016) 119-130.

D. Merli, A. Profumo, C. Dossi, Journal of Pharmaceutical Analysis 2 (2012) 450-453.

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Published

19-05-2020

How to Cite

Liu, H., Yu, Q., Ma, Y., Liu, B., & Pan, H. (2020). Cyclic voltammetry: A simple method for determining contents of total and free iron ions in sodium ferric gluconate complex. Journal of Electrochemical Science and Engineering, 10(3), 281–291. https://doi.org/10.5599/jese.749

Issue

Vol. 10 No. 3 (2020)

Section

Electrochemical Science

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