Dissolution rate of ciprofloxacin and its cocrystal with resorcinol

Authors

  • Clara Ràfols University of Barcelona
  • Hanan Fael
  • Elisabet Fuguet University of Barcelona
  • Breeze Outhwaite Sirius Analytical
  • Samuel Lee Sirius Analytical
  • Rebeca Ruiz Sirius Analytical

DOI:

https://doi.org/10.5599/admet.6.1.497

Abstract

The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate. In this work the dissolution rate of ciprofloxacin, a zwitterionic fluoroquinolone antibiotic, has been compared to its cocrystal with resorcinol. To this end, dissolution rate has been determined at several biorelevant pH values, and also in two simulated gastrointestinal fluids (FeSSIF and FaSSIF). Results show that both, ciprofloxacin and the cocrystal, dissolve more slowly as pH increases (from 2.0 to 7.4), as ionization degree of ciprofloxacin decreases. In addition, dissolution is not enhanced by the components of the gastrointestinal fluids.

Downloads

Download data is not yet available.

Downloads

Published

25-03-2018

How to Cite

Ràfols, C., Fael, H., Fuguet, E., Outhwaite, B., Lee, S., & Ruiz, R. (2018). Dissolution rate of ciprofloxacin and its cocrystal with resorcinol. ADMET and DMPK, 6(1), 61–70. https://doi.org/10.5599/admet.6.1.497

Issue

Section

Short Communications

Most read articles by the same author(s)