Vol. 4 No. 2 (2016) | ADMET and DMPK

Vol. 4 No. 2 (2016)

Changing trends in use of hepatocytes and microsomes for evaluating metabolism studies in drug discovery

Guest editor: Abdul Naveed Shaik

Published: 29-06-2016

Editorial

Changing trends in use of hepatocytes and microsomes for evaluating metabolism studies in drug discovery

Abdul Naveed Shaik

ADMET and DMPK, Vol. 4 No. 2 (2016), 60-61

Published 29-06-2016;

DOI: https://doi.org/10.5599/admet.4.2.320
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Original Scientific Articles

Pharmacogenetic profiling and metabolic activity of human embryonic stem cell derived hepatocytes: focus on CYP450-mediated oxidation

Jenna L. Voellinger, Edward J. Kelly

ADMET and DMPK, Vol. 4 No. 2 (2016), 62-83

Published 29-06-2016;

DOI: https://doi.org/10.5599/admet.4.2.280
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Metabolism of six CYP probe substrates in fetal hepatocytes

Abdul Naveed Shaik, Sandeep Kumar Vishwakarma, Aleem A Khan

ADMET and DMPK, Vol. 4 No. 2 (2016), 84-90

Published 29-06-2016;

DOI: https://doi.org/10.5599/admet.4.2.210
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Calendula officinalis L. (Asteraceae) possess antioxidant properties on Fe2+-initiated peroxidation of rat brain microsomes

Alejandro Palacios, Javier Barberón, Patricio Leaden, Pedro Zeinsteger

ADMET and DMPK, Vol. 4 No. 2 (2016), 91-97

Published 29-06-2016;

DOI: https://doi.org/10.5599/admet.4.2.251
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Defining desirable natural product derived anticancer drug space: optimization of molecular physicochemical properties and ADMET attributes

Deepika Singh

ADMET and DMPK, Vol. 4 No. 2 (2016), 98-113

Published 29-06-2016;

DOI: https://doi.org/10.5599/admet.4.2.291
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Opinions

Is there a paradigm shift in use of microsomes and hepatocytes in drug discovery and development?

Sumit Basu, Abdul Naveed Shaik

ADMET and DMPK, Vol. 4 No. 2 (2016), 114-116

Published 29-06-2016;

DOI: https://doi.org/10.5599/admet.4.2.317
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White papers

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

Alex Avdeef, Elisabet Fuguet, Antonio Llinàs, Clara Ràfols, Elisabeth Bosch, Gergely Völgyi, Tatjana Verbić, Elena Boldyreva, Krisztina Takács-Novák

ADMET and DMPK, Vol. 4 No. 2 (2016), 117-178

Published 29-06-2016;

DOI: https://doi.org/10.5599/admet.4.2.292
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Education

Explore postgraduate biomedical engineering course integration between medical signal processing and drug development: example for drug development in brain disease

Yin Tian, Li Yang, Zhongyan Wang, Huiling Zhang, Wei Xu, Shuxing Zheng, Haying Zhang, Dechun Zhao

ADMET and DMPK, Vol. 4 No. 2 (2016), 179-181

Published 03-07-2016;

DOI: https://doi.org/10.5599/admet.4.2.325
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