Electrochemical determination of paracetamol and chlorpheniramine  using AuNPs-rGO modified glassy carbon electrode: Original scientific paper

Huynh Van Chung; Nguyen Hai Phong; Dao Thi Cam Minh; Ho Xuan Anh Vu; Pham Khac Lieu; Nguyen Thi Thanh Huyen; Trinh Ngoc Dat; Doan Manh Dung; Do Thi Duyen; Dinh Quang Khieu

doi:10.5599/jese.2841

Authors

Huynh Van Chung University of Sciences, Hue University, Hue City, Vietnam and Faculty of Pharmacy, Buon Ma Thuot Medical University, Buon Ma Thuot City, Vietnam https://orcid.org/0000-0001-7519-1196
Nguyen Hai Phong University of Sciences, Hue University, Hue City, Vietnam https://orcid.org/0000-0001-5354-1052
Dao Thi Cam Minh University of Medicine and Pharmacy, Hue University, Hue City, Vietnam https://orcid.org/0000-0003-0786-3178
Ho Xuan Anh Vu University of Sciences, Hue University, Hue City, Vietnam https://orcid.org/0000-0001-7685-2320
Pham Khac Lieu University of Sciences, Hue University, Hue City, Vietnam https://orcid.org/0000-0002-9002-1416
Nguyen Thi Thanh Huyen Institute of Research and Development, Duy Tan University, Danang City, Vietnam https://orcid.org/0009-0006-8534-0662
Trinh Ngoc Dat University of Education and Science, The University of Danang, Danang City, Vietnam https://orcid.org/0009-0009-9941-2630
Doan Manh Dung Institute of Biotechnology and Environment, Tay Nguyen University, Buon Ma Thuot, Vietnam https://orcid.org/0000-0002-1229-7839
Do Thi Duyen Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi city, Vietnam https://orcid.org/0009-0004-3265-5084
Dinh Quang Khieu University of Sciences, Hue University, Hue City, Vietnam https://orcid.org/0000-0003-3473-6377

DOI:

https://doi.org/10.5599/jese.2841

Keywords:

Drug sensors, square-wave anodic stripping voltammetry, ochemically reduced graphene oxide, herbal medicine

Abstract

One of the significant durability challenges is the corrosion of reinforced concrete. A gold nanoparticle/reduced graphene oxide modified glassy carbon electrode (AuNPs-rGO-GCE) was fabricated using an electrochemical reduction method for the simultaneous determination of paracetamol (PAR) and chlorpheniramine maleate (CPM). AuNPs-rGO modified GC electrodes were prepared through direct electrochemical reduction of GO to rGO, followed by direct reduction of Au ions to Au on the rGO matrix. X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectra, Raman spectroscopy, energy dispersive X-ray spectroscopy, high-resolution transmission electron microscopy, electrochemical impedance spectroscopy, and X-ray photoelectron spectroscopy characterized the resulting AuNPs-rGO. It was found that AuNPs around 15.4 nm were highly dispersed on the rGO. The modification of GCE by AuNPs-rGO accelerates the electron transfer process and increases the conductivity of the electrode. The AuNPs-rGO modified electrode was used to simultaneously determine PAR and CPM using the square-wave anodic stripping voltammetry (SQW-ASV) method. Under suitable experimental conditions, the SQW-ASV method using AuNPs-rGO-GCE showed a wide linear range from 23.7 to 140.0 µM for PAR and from 7.5 to 54.0 µM for CPM. The limit of detection of PAR and CPM was 7.12 and 2.54 µM, respectively. The proposed SQW-ASV method was applied to analyze PAR and CPM in samples of herbal medicine simultaneously, and the results were compared with those of high-performance liquid chromatography, with no statistical difference.

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Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode

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