Tadalafil electrooxidation on gold and MWCNT-based nanocomposites modified carbon paste electrodes: comparative study and analytical application

Original scientific paper

Authors

  • Jasmina Anojčić University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry, and Environmental Protection, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia https://orcid.org/0000-0002-2750-1994
  • Sanja Mutić University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry, and Environmental Protection, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia https://orcid.org/0000-0003-3659-0455
  • Sanja Stevanović University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Electrochemistry, Njegoševa 12, 11000 Belgrade, Serbia https://orcid.org/0000-0003-2157-5754
  • Nebojša D. Nikolić University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Electrochemistry, Njegoševa 12, 11000 Belgrade, Serbia https://orcid.org/0000-0002-6385-5714
  • Dušan Mijin University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia https://orcid.org/0000-0001-5691-2971
  • Slobodan Petrović University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia https://orcid.org/0000-0002-4239-0970
  • Zoltán Kónya Department of Applied and Environmental Chemistry, University of Szeged, Rerrich Béla tér 1, 6720 Szeged, Hungary https://orcid.org/0000-0002-9406-8596
  • Milka Avramov Ivić University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Department of Electrochemistry, Njegoševa 12, 11000 Belgrade, Serbia https://orcid.org/0000-0001-6127-1216

DOI:

https://doi.org/10.5599/jese.3459

Keywords:

Pharmaceuticals, electroanalysis, electrochemical sensors, voltammetry, pharmaceutical formulation, human blood serum sample

Abstract

The electrochemical behaviour of tadalafil (TAD) was investigated using a solid gold electrode and carbon paste electrodes (CPE) modified with multiwalled carbon nanotubes (MWCNT) or their nanocomposites with noble metal particles (Ag-MWCNT and Au-MWCNT). Cyclic voltammetric study revealed that the oxidation of TAD is irreversible and that adsorption plays a significant role in the oxidation mechanism. Among the investigated electrodes, the Au-MWCNT/CPE exhibited the best electroanalytical performance and was used to develop a sensitive and reliable square-wave adsorptive stripping voltammetric method for TAD determination in Britton-Robinson buffer solution as supporting electrolyte. The optimal pH was 4.0, with target analyte accumulation being most pronounced at Eacc = 0.6 V and tacc = 10 s. Linearity was obtained in the TAD concentration range of 0.10 to 1.96 µg mL-1, with calculated limit of detection of 0.03 µg mL-1. The constructed sensor showed excellent repeatability and reproducibility, as well as anti-interference ability, making it highly suitable for analytical applications, such as the quantification of TAD in the pharmaceutical formulation Cialis® and in human blood serum sample.

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Published

07-07-2026

Issue

Vol. 16 (2026)

Section

Electroanalytical chemistry

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Copyright (c) 2026 Jasmina Anojčić, Sanja Mutić, Sanja Stevanović, Nebojša D. Nikolić, Dušan Mijin, Slobodan Petrović, Zoltán Kónya, Milka Avramov Ivić

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How to Cite

Tadalafil electrooxidation on gold and MWCNT-based nanocomposites modified carbon paste electrodes: comparative study and analytical application: Original scientific paper. (2026). Journal of Electrochemical Science and Engineering, 16, Article 3459. https://doi.org/10.5599/jese.3459

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