Fabrication of iridium-gold nanocomposite for the detection of selective serotonin reuptake inhibitors
Original scientific paper
DOI:
https://doi.org/10.5599/jese.2919Keywords:
Coffee (Coffea arabica L.) waste, green nanotechnology, bimetallic nanoparticles, citalopram, paroxetine, electrochemical sensorAbstract
A comprehensive study of the development of a novel electrochemical sensor based on iridium-gold nanocomposite (IrAuNPs) modified electrodes for the detection of antidepressants, paroxetine (PRX) and citalopram (CIT) was conducted. The sensing platform, based on a glassy carbon electrode, was modified by drop-casting IrAuNPs, which allowed for enhanced conductivity. IrAuNPs, along with their counterparts iridium nanoparticles (IrNPs) and gold nanoparticles (AuNPs), were synthesized from coffee waste extract (CWE) via complete green chemistry. The physicochemical properties of synthesized nanomaterials were characterized using ultraviolet-visible spectroscopy, dynamic light scattering, high-resolution transmission electron microscopy, Fourier-transform infrared spectroscopy, cyclic voltammetry and square wave voltammetry. Results showed that the CWE could reduce the respective metallic salts to form mostly near-spherical to spherical IrAuNPs, IrNPs and AuNPs with core sizes ranging from 2.02 nm to 13.27 nm. The electrochemical sensor could determine PRX and CIT in the concentration ranges of 20 to 200 nM and 1 to 10 µM, with detection limits of 0.072 nM and 0.085 µM, respectively. The sensor showed a recovery of 86 to 115.1 %. The proposed sensor demonstrated good precision and accuracy, with excellent sensitivity and selectivity for drug identification in a rapid analysis time, which is crucial for applications in biological matrices.
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[1] R. Das, Y. K. Agrawal, Trends and Advances in Separation and Detection of SSRIs and SNRIs in Biological Matrices, Chromatography Research International 2013 (2013) 139459. https://doi.org/10.1155/2013/139459 DOI: https://doi.org/10.1155/2013/139459
[2] Z. Pan, C. Park, E. Brietzke, H. Zuckerman, C. Rong, R. B. Mansur, D. Fus, M. Subramaniapillai, Y. Lee, R.S. McIntyre, Cognitive impairment in major depressive disorder, CNS Spectrums 24 (2019) 22-29. https://doi.org/10.1017/S1092852918001207 DOI: https://doi.org/10.1017/S1092852918001207
[3] M. Feroz, I.C. Lopes, H. ur Rehman, S. Ata, P. Vadgama, A novel molecular imprinted polymer layer electrode for enhanced sensitivity electrochemical determination of the antidepressant fluoxetine, Journal of Electroanalytical Chemistry 878 (2020) 114693. https://doi.org/10.1016/j.jelechem.2020.114693 DOI: https://doi.org/10.1016/j.jelechem.2020.114693
[4] A. Hassan Oghli, A. Soleymanpour, Ultrasensitive electrochemical sensor for simultaneous determina¬tion of sumatriptan and paroxetine using molecular imprinted polymer/sol-gel/polyoxometalate/rGO modified pencil graphite electrode, Sensors Actuators B 344 (2021) 130215. https://doi.org/10.1016/j.snb.2021.130215 DOI: https://doi.org/10.1016/j.snb.2021.130215
[5] N. Naz, S. N. Ali, A. Qayoom, S. Iqbal, S. Akram, Rapid and sensitive method for simultaneous determination of citalopram with antihistamines by liquid chromatography, Pakistan Journal of Pharmaceutical Sciences 34 (2021) 835-841. https://doi.org/10.36721/PJPS.2021.34.3.REG.835-841.1 DOI: https://doi.org/10.36721/PJPS.2021.34.3.REG.835-841.1
[6] M. B. Gholivand, A. Akbari, A novel voltammetric sensor for citalopram based on multiwall carbon nanotube/(poly(p-aminobenzene sulfonic acid)/β-cyclodextrin), Material Science and Engineering: C 62 (2016) 480-488. https://doi.org/10.1016/j.msec.2016.01.066. DOI: https://doi.org/10.1016/j.msec.2016.01.066
[7] F. Faridbod, N. Davarkhah, S. Karamdoust, All solid sate potentiometric sensors for the measurement of paroxetine in pharmaceutical formulation, International Journal of Electrochemical Science 10 (2015) 8308-8320. https://doi.org/10.1016/S1452-3981(23)11097-2 DOI: https://doi.org/10.1016/S1452-3981(23)11097-2
[8] R. Nimal, D. Nur Unal, C. Erkmen, S. Kurbanoglu, M. Siddiq, G. Eren, A. Shah, B. Uslu, Elucidating the interaction of antidepressant drug paroxetine with ct-dsDNA: A comparative study by electrochemical, spectroscopic, and molecular docking approaches, Bioelectrochemistry 149 (2023) 108285. https://doi.org/10.1016/j.bioelechem.2022.108285 DOI: https://doi.org/10.1016/j.bioelechem.2022.108285
[9] Y. Ma, C. Wang, S. Luo, B. Li, T. D. Wager, W. Zhang, Y. Rao, S. Han, Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain, Neuroimage 135 (2016) 186-196. https://doi.org/10.1016/j.neuroimage.2016.04.064 DOI: https://doi.org/10.1016/j.neuroimage.2016.04.064
[10] C. Ran, H. Zhou, C. Tan, J. Tan, Z. Zhang, W. Zhao, Detection and Evaluation of Adverse Drug Reaction Signals of Antidepressants Based on FDA Adverse Event Reporting System Database, Open Journal of Depression 09 (2020) 17-25. https://doi.org/10.4236/ojd.2020.92002 DOI: https://doi.org/10.4236/ojd.2020.92002
[11] P. Magalhães, G. Alves, A. Llerena, A. Falcão, Therapeutic drug monitoring of fluoxetine, norfluoxetine and paroxetine: A new tool based on microextraction by packed sorbent coupled to liquid chromatography, Journal of Analytical Toxicology 41 (2017) 631-638. https://doi.org/10.1093/jat/bkx043 DOI: https://doi.org/10.1093/jat/bkx043
[12] A. Roszkowska, A. Plenis, P. Kowalski, T. Bączek, I. Olędzka, Recent advancements in techniques for analyzing modern, atypical antidepressants in complex biological matrices and their application in biomedical studies, TrAC Trends in Analytical Chemistry 152 (2022) 116609. https://doi.org/10.1016/j.trac.2022.116609 DOI: https://doi.org/10.1016/j.trac.2022.116609
[13] S. L. Aldrich, E. A. Poweleit, C. A. Prows, L. J. Martin, J. R. Strawn, L. B. Ramsey, Influence of CYP2C19 metabolizer status on escitalopram/citalopram tolerability and response in youth with anxiety and depressive disorders, Frontiers in Pharmacology 10 (2019) 99. https://doi.org/10.3389/fphar.2019.00099 DOI: https://doi.org/10.3389/fphar.2019.00099
[14] M. H. Karimi-Harandi, M. Shabani-Nooshabadi, R. Darabi, Simultaneous determination of citalopram and selegiline using an efficient electrochemical sensor based on ZIF-8 decorated with RGO and g-C3N4 in real samples, Analytica Chimica Acta 1203 (2022) 339662. https://doi.org/10.1016/j.aca.2022.339662 DOI: https://doi.org/10.1016/j.aca.2022.339662
[15] G. Mannocchi, R. Tittarelli, F. Pantano, F. Vernich, M. Pallocci, P. Passalacqua, M. Treglia, L. T. Marsella, Forensic Aspects of a Fatal Intoxication Involving Acetaminophen, Citalopram and Trazodone: A Case Report, Toxics 10 (2022) 486. https://doi.org/10.3390/toxics10080486 DOI: https://doi.org/10.3390/toxics10080486
[16] A. H. Oghli, A. Soleymanpour, Polyoxometalate/reduced graphene oxide modified pencil graphite sensor for the electrochemical trace determination of paroxetine in biological and pharmaceutical media, Materials Science and Engineering C 108 (2020) 110407. https://doi.org/10.1016/j.msec.2019.110407 DOI: https://doi.org/10.1016/j.msec.2019.110407
[17] J. Xu, J. Tao, L. Su, J. Wang, T. Jiao, A critical review of carbon quantum dots: From synthesis toward applications in electrochemical biosensors for the determination of a depression-related neurotransmitter, Materials (Basel) 14 (2021) 3987. https://doi.org/10.3390/ma14143987 DOI: https://doi.org/10.3390/ma14143987
[18] K. Murtada, F. de Andrés, M. Zougagh, Á. Ríos, Strategies for antidepressants extraction from biological specimens using nanomaterials for analytical purposes: A review, Microchemical Journal 150 (2019) 104193. https://doi.org/10.1016/j.microc.2019.104193 DOI: https://doi.org/10.1016/j.microc.2019.104193
[19] M. Brycht, S. Skrzypek, N. Karadas-Bakirhan, S. Smarzewska, B. Bozal-Palabiyik, S. A. Ozkan, B. Uslu, Voltammetric behavior and determination of antidepressant drug paroxetine at carbon-based electrodes, Ionics (Kiel) 21 (2015) 2345-2354. https://doi.org/10.1007/s11581-015-1390-6 DOI: https://doi.org/10.1007/s11581-015-1390-6
[20] A. A. Abu-hassan, M. A. Omar, S. M. Derayea, Use of acetylacetone for nano-level assay of fluvoxamine maleate in pure form and pharmaceutical formulation, Luminescence 35 (2020) 1360-1365. https://doi.org/10.1002/bio.3898 DOI: https://doi.org/10.1002/bio.3898
[21] A. G. dos Santos Neto, C. S. de Sousa, A. da Silva Freires, S. M. Silva, H. Zanin, F. S. Damos, R. de Cássia Silva Luz, Electrochemical sensor for detection of imipramine antidepressant at low potential based on oxidized carbon nanotubes, ferrocenecarboxylic acid, and cyclodextrin: application in psychotropic drugs and urine samples, Journal of Solid State Electrochemistry 22 (2018) 1385-1394. https://doi.org/10.1007/s10008-017-3772-3 DOI: https://doi.org/10.1007/s10008-017-3772-3
[22] F. C. O. L. Martins, L. C. Pimenta, D. De Souza, Antidepressants determination using an electroanalytical approach: A review of methods, Journal of Pharmaceutical and Biomedical Analysis 206 (2021) 114365. https://doi.org/10.1016/j.jpba.2021.114365 DOI: https://doi.org/10.1016/j.jpba.2021.114365
[23] T. T. T. Tran, D. M. Nguyen, A. Q. Dao, V. T. Le, Y. Vasseghian, A state-of-the-art review on the nanomaterial-based sensor for detection of venlafaxine, Chemosphere 297 (2022) 134116. https://doi.org/10.1016/j.chemosphere.2022.134116 DOI: https://doi.org/10.1016/j.chemosphere.2022.134116
[24] S. Sharma, N. Singh, V. Tomar, R. Chandra, A review on electrochemical detection of serotonin based on surface modified electrodes, Biosensors and Bioelectronics 107 (2018) 76-93. https://doi.org/10.1016/j.bios.2018.02.013 DOI: https://doi.org/10.1016/j.bios.2018.02.013
[25] W. Jin, G. Maduraiveeran, Nanomaterial-based environmental sensing platforms using state-of-the-art electroanalytical strategies, Journal of Analytical Science and Technology 9 (2018) 18. https://doi.org/10.1186/s40543-018-0150-4 DOI: https://doi.org/10.1186/s40543-018-0150-4
[26] A. K. Attia, M. A. Mohamed, A. M. Fekry, Electroanalytical determination of escitalopram oxalate using nickel nanoparticles modified carbon paste sensor, Acta Chimica Slovenica 64 (2017) 415-421. https://doi.org/10.17344/acsi.2017.3193 DOI: https://doi.org/10.17344/acsi.2017.3193
[27] M.A . Sultan, A. K. Attia, M. M. Abou El-Alamin, M. A Atia, The novel use of multiwalled carbon nanotubes based sensors for voltammetric determination of itraconazole: application to pharmaceutical dosage form and biological samples through spiked urine samp, World Journal of Pharmacy and Pharmaceutical Sciences 5 (2016) 93-108. https://www.researchgate.net/profile/Ali-Attia3/publication/305851485
[28] J. M. Pingarrón, P. Yáñez-Sedeño, A. González-Cortés, Gold nanoparticle-based electrochemical biosensors, Electrochimica Acta 53 (2008) 5848-5866 https://doi.org/10.1016/j.electacta.2008.03.005 DOI: https://doi.org/10.1016/j.electacta.2008.03.005
[29] Y. Zhao, E. A. Hernandez-Pagan, N. M. Vargas-Barbosa, J. L. Dysart, T. E. Mallouk, A high yield synthesis of ligand-free iridium oxide nanoparticles with high electrocatalytic activity, The Journal of Physical Chemistry Letters 2 (2011) 402-406. https://doi.org/10.1021/jz200051c DOI: https://doi.org/10.1021/jz200051c
[30] Z. Wei, K. Luciano, X. Xia, Catalytic Gold-Iridium Nanoparticles as Labels for Sensitive Colorimetric Lateral Flow Assay, ACS Nano 16 (2022) 21609-21617. https://doi.org/10.1021/acsnano.2c10574 DOI: https://doi.org/10.1021/acsnano.2c10574
[31] G. Ghodake, C.Y. Eom, S. W. Kim, E. Jin, Biogenic nano-synthesis; Towards the efficient production of the biocompatible gold nanoparticles, Bulletin of the Korean Chemical Society 31 (2010) 2771-2775. https://doi.org/10.5012/bkcs.2010.31.10.2771 DOI: https://doi.org/10.5012/bkcs.2010.31.10.2771
[32] A. M. Elbagory, C. N. Cupido, M. Meyer, A. A. Hussein, Large scale screening of southern African plant extracts for the green synthesis of gold nanoparticles using microtitre-plate method, Molecules 21 (2016) 1498. https://doi.org/10.3390/molecules21111498 DOI: https://doi.org/10.3390/molecules21111498
[33] M. Cui, Y. Zhao, C. Wang, Q. Song, Synthesis of 2.5 nm colloidal iridium nanoparticles with strong surface enhanced Raman scattering activity, Microchimica Acta 183 (2016) 2047-2053. https://doi.org/10.1007/s00604-016-1846-z DOI: https://doi.org/10.1007/s00604-016-1846-z
[34] R. W. Raut, A. S. M. Haroon, Y. S. Malghe, B. T. Nikam, S. B. Kashid, Rapid biosynthesis of platinum and palladium metal nanoparticles using root extract of asparagus racemosus linn, Advanced Materials Letters 4 (2013) 650-654. https://doi.org/10.5185/amlett.2012.11470 DOI: https://doi.org/10.5185/amlett.2012.11470
[35] T. L. H. Nguyen, V.-D. Doan, Q.-H. Tran, A.T. Nguyen, A.V. Tran, V. T. Le, A. Renat Maratovich, H. Y. Hoang, Magnetic composite - Based dual nanozymes derived from coffee ground waste: A sustainable approach for colorimetric assay and prolonged reuse, Microchemical Journal 200 (2024) 110343. https://doi.org/10.1016/j.microc.2024.110343 DOI: https://doi.org/10.1016/j.microc.2024.110343
[36] M. Cui, C. Wang, D. Yang, Q. Song, Fluorescent iridium nanoclusters for selective determination of chromium(VI), Microchimica Acta 185 (2018) 8. https://doi.org/10.1007/s00604-017-2553-0 DOI: https://doi.org/10.1007/s00604-017-2553-0
[37] B. Wu, J. Yang, Y. Zu, J. Chi, K. Shi, Aligned electrospun fiber film loaded with multi ‑ enzyme mimetic iridium nanozymes for wound healing, Journal of Nanobiotechnology 20 (2022) 478. https://doi.org/10.1186/s12951-022-01685-2 DOI: https://doi.org/10.1186/s12951-022-01685-2
[38] M. Madej, D. Matoga, K. Skaźnik, R. Porada, B. Baś, J. Kochana, A voltammetric sensor based on mixed proton-electron conducting composite including metal-organic framework JUK-2 for determination of citalopram, Microchimica Acta 188 (2021) 184. https://doi.org/10.1007/s00604-021-04835-9 DOI: https://doi.org/10.1007/s00604-021-04835-9
[39] A. Singh, P.K. Gautam, A. Verma, V. Singh, P. M. Shivapriya, S. Shivalkar, A. K. Sahoo, S. K. Samanta, Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections, Biotechnology Reports 25 (2020) e00427. https://doi.org/10.1016/j.btre.2020.e00427 DOI: https://doi.org/10.1016/j.btre.2020.e00427
[40] Y. Peng, Q. Liu, B. Lu, T. He, F. Nichols, X. Hu, T. Huang, G. Huang, L. Guzman, Y. Ping, S. Chen, Organically Capped Iridium Nanoparticles as High-Performance Bifunctional Electrocatalysts for Full Water Splitting in Both Acidic and Alkaline Media: Impacts of Metal-Ligand Interfacial Interactions, ACS Catalysis Journal 11 (2021) 1179-1188. https://doi.org/10.1021/acscatal.0c03747 DOI: https://doi.org/10.1021/acscatal.0c03747
[41] J. Quinson, Iridium and IrOx nanoparticles: an overview and review of syntheses and applications, Advances in Colloid and Interface Science 303 (2022) 102643. https://doi.org/10.1016/j.cis.2022.102643 DOI: https://doi.org/10.1016/j.cis.2022.102643
[42] A. E. F. Oliveira, C. Arnaldo, M. A. C. Resende, L. F. Ferreira, Gold Nanoparticles: A Didactic Step-by-Step of the Synthesis Using the Turkevich Method, Mechanisms, and Characterizations, Analytica 4 (2023) 250-263. https://doi.org/10.3390/analytica4020020 DOI: https://doi.org/10.3390/analytica4020020
[43] Y. Yi, G. Weinberg, M. Prenzel, M. Greiner, S. Heumann, S. Becker, R. Schlögl, Electrochemical corrosion of a glassy carbon electrode, Catalysis Today 295 (2017) 32-40. https://doi.org/10.1016/j.cattod.2017.07.013 DOI: https://doi.org/10.1016/j.cattod.2017.07.013
[44] H. Keypour, S. G. Saremi, H. Veisi, M. Noroozi, Electrochemical determination of citalopram on new Schiff base functionalized magnetic Fe3O4 nanoparticle/MWCNTs modified glassy carbon electrode, Journal of Electroanalytical Chemistry 780 (2016) 160-168. https://doi.org/10.1016/j.jelechem.2016.08.022 DOI: https://doi.org/10.1016/j.jelechem.2016.08.022
[45] R. Piech, M. Rumin, B. Paczosa-Bator, High sensitive voltammetric determination of paroxetine on glassy carbon electrode modified with Nafion/MWCNTs, International Journal of Electrochemical Science 9 (2014) 7528-7539. https://doi.org/10.1016/S1452-3981(23)10985-0 DOI: https://doi.org/10.1016/S1452-3981(23)10985-0
[46] C. G. Sanz, S. H. P. Serrano, C. M. A. Brett, Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes, ChemElectroChem 7 (2020) 2151-2158. https://doi.org/10.1002/celc.202000255 DOI: https://doi.org/10.1002/celc.202000255
[47] H. Nouws, C. Delerue-Matos, A. Barros, Electrochemical determination of citalopram by adsorptive stripping voltammetry-determination in pharmaceutical products, Analytical Letters 39 (2006) 1907-1915. https://doi.org/10.1080/00032710600721712 DOI: https://doi.org/10.1080/00032710600721712
[48] T. Madrakian, M. Soleimani, A. Afkhami, Electrochemical determination of fluvoxamine on mercury nanoparticle multi-walled carbon nanotube modified glassy carbon electrode, Sensors and Actuators: B Chemical 210 (2015) 259-266. https://doi.org/10.1016/j.snb.2014.12.074 DOI: https://doi.org/10.1016/j.snb.2014.12.074
[49] N. O. Gomes, C. D. Mendonça, S. A. S. Machado, O. N. Oliveira, P. A. Raymundo-Pereira, Flexible and integrated dual carbon sensor for multiplexed detection of nonylphenol and paroxetine in tap water samples, Microchimica Acta 188 (2021) 359. https://doi.org/10.1007/s00604-021-05024-4 DOI: https://doi.org/10.1007/s00604-021-05024-4
[50] S. R. Al-Mhyawi, R. K. Ahmed, R. M. El Nashar, Application of a conducting poly-methionine/gold nanoparticles-modified sensor for the electrochemical detection of paroxetine, Polymers (Basel) 13 (2021) 3981. https://doi.org/10.3390/polym13223981 DOI: https://doi.org/10.3390/polym13223981
[51] R. F. Ajayi, E. Nxusani, S. F. Douman, A. Jonnas, P. G. L. Baker, E. I. Iwuoha, An amperometric cytochrome P450-2D6 biosensor system for the detection of the selective serotonin reuptake inhibitors (SSRIs) paroxetine and fluvoxamine, Journal of Nano Research 44 (2016) 208-228. https://doi.org/10.4028/www.scientific.net/JNanoR.44.208 DOI: https://doi.org/10.4028/www.scientific.net/JNanoR.44.208
[52] L. Daneshvar, G. H. Rounaghi, Z. Es’haghi, M. Chamsaz, S. Tarahomi, Fabrication a new modified electrochemical sensor based on Au-Pd bimetallic nanoparticle decorated graphene for citalopram determination, Material Science and Engineering: C 69 (2016) 653-660. https://doi.org/10.1016/j.msec.2016.07.025 DOI: https://doi.org/10.1016/j.msec.2016.07.025
[53] H. Ghaedi, A. Afkhami, T. Madrakian, F. Soltani-Felehgari, Construction of novel sensitive electrochemical sensor for electro-oxidation and determination of citalopram based on zinc oxide nanoparticles and multi-walled carbon nanotubes, Material Science and Engineering: C 59 (2016) 847-854. https://doi.org/10.1016/j.msec.2015.10.088 DOI: https://doi.org/10.1016/j.msec.2015.10.088
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Copyright (c) 2025 Simone Barry, Rachel Fanelwa Ngece-Ajayi, Keagan Pokpas, Candice Cupido, Takalani Mulaudzi
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National Research Foundation
Grant numbers UID: 118469;UID: 116258
