Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development

Authors

  • Abdul Naveed Shaik Simulations Plus Inc., Lancaster, CA. USA http://orcid.org/0000-0002-3672-2246
  • Ansar Ali Khan GVK Biosciences Ltd, Hyderabad, TS. India

DOI:

https://doi.org/10.5599/admet.667

Keywords:

PBPK, Drug Development, Model based drug development

Abstract

Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic or physiology based mathematical modeling technique which integrates the knowledge from both drug-based properties including physiochemical and biopharmaceutical properties and system based or physiological properties to generate a model for predicting the absorption, distribution, metabolism and excretion (ADME) properties of a drug as well as pharmacokinetic behavior of a drug in preclinical species and humans.

Downloads

Download data is not yet available.

Downloads

Published

23-02-2019

How to Cite

Shaik, A. N., & Khan, A. A. (2019). Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development. ADMET and DMPK, 7(1), 1–3. https://doi.org/10.5599/admet.667

Issue

Vol. 7 No. 1 (2019)

Section

Editorial

License

Creative Commons лиценца
Articles are published under the terms and conditions of the
Creative Commons Attribution license 4.0 International.