Electrochemical determination of methyldopa in the presence of hydrochlorothiazide using carbon paste electrode modified with MoS2/Ni- metal organic framework hybrid nanosheets
Original scientific paper
DOI:
https://doi.org/10.5599/admet.3620Keywords:
Hypertension, heart disease, oedema, diabetic insipidus, two-dimensional nanosheetsAbstract
Background and purpose: Methyldopa (MDP) and Hydrochlorothiazide (HCTZ) are advised for the treatment of essential hypertension. Electrochemical techniques are used for their determination in biological samples. Experimental approach: This study uses a carbon paste electrode (CPE) modified with MoS2 nanosheets and a nickel-based metal-organic framework (MSN-MOF/CPE sensor) for simultaneous voltammetric detection of MDP and HCTZ. Key results: Electrochemical analysis of the modified electrode revealed that, in comparison to an unmodified CPE, MDP oxidation takes place at about 100 mV lower potentials under ideal conditions. With a limit of detection (LOD) of 0.01 μM, the sensor shows a sensitive response to MDP in the range of 0.05 to 260.0 μM. Additionally, the MSN-MOF/CPE sensor showed high sensitivity for the simultaneous determination of MDP and HCTZ. The defined and separated oxidation peaks of a mixture of MDP and HCTZ showed significant peak potential differences of 240 mV. Conclusion: Ultimately, the suggested method was effectively used to determine MDP and HCTZ in pharmaceutical samples and urine as real samples.
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