Synthesis and characterization of bimetallic nanocomplex: Application for electrochemical determination of idarubicin as anti-cancer drug: Original scientific article

Thekrayat J Joodi Jassim; Raheem  Kubaish Barid; Haider  Dakhal Hamza

doi:10.5599/admet.3342

Authors

Thekrayat J Joodi Jassim College of Education, Department of Chemistry, University of Sumer, Thi_Qar, Iraq https://orcid.org/0009-0008-4113-401X
Raheem Kubaish Barid Al-Rifai High School for Outstanding Students, Al-Rifai ducation Department, Dhi Qar Education Directorate, Iraq https://orcid.org/0009-0008-7084-2875
Haider Dakhal Hamza Al-Qadisiyah Education Directorate, Iraq https://orcid.org/0009-0004-8522-0551

DOI:

https://doi.org/10.5599/admet.3342

Keywords:

Scanning electron microscopy, solvothermal process, antibacterial behaviour, screen-printed graphite electrode

Abstract

Background and purpose: Cancer chemotherapy with antineoplastic drugs destroys cancer cells through complete cell death or stops cell development while protecting healthy cells from damage. Monitoring anticancer therapeutics in blood and tissues is important for determining their fate. Experimental approach: A novel binuclear complex with the formula [Cu(opd)₂(H₂O)(μ-SCN)Ni(opd)(SCN)₃] (opd = o-phenylenediamine) was synthesized and characterized using Fourier transform infrared spectroscopy and UV-Vis spectroscopy. The solvothermal method was used to create a nanoscale version of the binuclear complex. X-ray powder diffraction, scanning electron microscopy, UV-Vis and FT-IR spectroscopy were used to characterize the nanocomplex. The solvothermal approach produced a nanocomplex with an average size of around 56 nm. The complex was tested for its antimicrobial properties on Gram-positive Staphylococcus aureus and Enterococcus faecalis, as well as Gram-negative Escherichia coli and Pseudomonas aeruginosa. Additionally, a screen-printed graphite electrode modified by a synthetic nanocomplex (Cu-Ni/SPGE) was presented as an improved electrochemical sensor for the detection of idarubicin (IRN). Key results: This sensor has a linear dynamic range from 0.01 to 3.0 μM and an impressive limit of detection of 0.003 μM under ideal testing circumstances. Conclusion: The researchers used a Cu-Ni/SPGE system to perform electrochemical measurements on IRN. The Cu-Ni/SPGE outperformed the untreated SPGE in terms of IRN oxidation. The antibacterial activity of the complex was also studied.

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