A high-performance voltammetric sensor based on Co/Ni-metal-organic framework modified electrode for the determination of dopamine in the presence of tyrosine: Original scientific article

Dhurgham Hani  Kadhim Alalwan; Saja Haider  Fadhil; Muntaha  Mahmood Abed; Noor Kareem  Aead; Hussein Ali Qabel

doi:10.5599/admet.3246

Authors

Dhurgham Hani Kadhim Alalwan Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Karbala, Iraq https://orcid.org/0009-0006-5229-2641
Saja Haider Fadhil Department of Clinical Laboratory Sciences, College of Pharmacy, University of Kerbala, Karbala, Iraq https://orcid.org/0009-0005-8939-3035
Muntaha Mahmood Abed Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Karbala, Iraq https://orcid.org/0009-0006-6758-8306
Noor Kareem Aead Department of Clinical Laboratory Sciences, College of Pharmacy, University of Kerbala, Karbala, Iraq https://orcid.org/0009-0001-4226-0949
Hussein Ali Qabel Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kerbala, Karbala, Iraq https://orcid.org/0009-0002-6609-6503

DOI:

https://doi.org/10.5599/admet.3246

Keywords:

Disposable sensor, differential pulse voltammetry, screen printed electrode, chronoamperometry, clic voltammetry, real sample analysis

Abstract

Background and purpose: The central nervous, renal, hormonal, and cardiovascular systems depend on dopamine. Therefore, a straightforward, sensitive, and selective method for detecting DA is needed to track DA levels in the human body. Experimental approach: Co/Ni-metal-organic framework was developed via a one-pot hydrothermal synthesis. The electrochemical sensor developed for dopamine measurement used Co/Ni-metal-organic framework materials on screen-printed carbon electrodes. The Co/Ni-metal-organic framework on a screen-printed carbon electrode exhibits excellent electrocatalytic activity for dopamine oxidation, owing to its high electron-transfer rate. Key results: The electrocatalytic activity of Co/Ni-metal-organic framework on a screen-printed carbon electrode significantly improves dopamine oxidation, yielding higher peak currents and lower oxidation potentials than the bare screen-printed carbon electrode. The sensor detected dopamine with a linear response, ranging from 0.01 to 660.0 µmol L^-1, with a limit of detection of 0.007 µmol L^-1. To measure tyrosine and dopamine simultaneously, differential pulse voltammetry was used. The separation between tyrosine and dopamine reached 150 mV. Conclusion: Successful target-analyte identification using the proposed voltammetric sensor was achieved, detecting both dopamine and tyrosine in actual sample tests.

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References

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