Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

  • Josef Jampilek Department of Chemical Drugs, Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
  • Radka Opatrilova Department of Chemical Drugs, Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic

Abstract

The investigation deals with the affection of permeation of mupirocin from the Bactroban® Leciva ointment through full-thickness pig ear skin by the original Czech compound (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, known under the international non-proprietary name of “alaptide“, in micronized or nanonized form. It was found out that micronized alaptide significantly enhanced the permeation of mupirocin within 1 h after administration (approx. 5-fold). On the other hand, nanonized alaptide almost completely inhibited permeation of mupirocin from Bactroban® Leciva through the skin. Rapid primary screening showed that the two forms of alaptide influence differently the depth and the rate of permeation/penetration of mupirocin into/through the skin, i.e. affect curative effect of mupirocin on/in skin immediately after application of drug formulation.

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Published
01-04-2014
Section
Original Scientific Articles