Synthesis and diverse biological activity profile of triethylammonium isatin-3-hydrazones

Andrei Bogdanov; Olga  Tsivileva; Alexandra  Voloshina; Anna Lyubina; Syumbelya Amerhanova; Ekaterina Burtceva; Sergey Bukharov; Alexander Samorodov; Valentin Pavlov

doi:10.5599/admet.1179

Authors

Andrei Bogdanov Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, Russian Federation https://orcid.org/0000-0002-2483-4742
Olga Tsivileva Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences, Saratov 410049, Russian Federation https://orcid.org/0000-0002-5269-349X
Alexandra Voloshina Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Anna Lyubina Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Syumbelya Amerhanova Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Ekaterina Burtceva Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Sergey Bukharov Kazan National Research Technological University, Kazan 420015, Russian Federation
Alexander Samorodov Bashkir State Medical University, Ufa 450000, Russian Federation
Valentin Pavlov Bashkir State Medical University, Ufa 450000, Russian Federation

DOI:

https://doi.org/10.5599/admet.1179

Abstract

A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR- and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo- and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time.