Synthesis and diverse biological activity profile of triethylammonium isatin-3-hydrazones

  • Andrei Bogdanov Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, Russian Federation https://orcid.org/0000-0002-2483-4742
  • Olga Tsivileva Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences, Saratov 410049, Russian Federation https://orcid.org/0000-0002-5269-349X
  • Alexandra Voloshina Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
  • Anna Lyubina Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
  • Syumbelya Amerhanova Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
  • Ekaterina Burtceva Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
  • Sergey Bukharov Kazan National Research Technological University, Kazan 420015, Russian Federation
  • Alexander Samorodov Bashkir State Medical University, Ufa 450000, Russian Federation
  • Valentin Pavlov Bashkir State Medical University, Ufa 450000, Russian Federation
isatin hydrazones

Abstract

A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR- and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo- and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time.

 

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Published
13-01-2022
Section
Original Scientific Articles