Electrochemical study of olanzapine transfer across the water/1,2-dichloroethane interface

Original scientific paper

Authors

  • Renata Ailen Rodríguez Paz Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila. Blvd. V. Carranza s/n, Saltillo Coahuila, 25280, México https://orcid.org/0009-0002-0932-4813
  • Luis Gonzalo López-Martínez Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila. Blvd. V. Carranza s/n, Saltillo Coahuila, 25280, México and Universidad del Mar, Campus Puerto Ángel. Ciudad Universitaria, Puerto Ángel, San Pedro Pochutla, Oaxaca, 70902, México https://orcid.org/0009-0003-2549-7404
  • Judith Amador-Hernández Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila. Blvd. V. Carranza s/n, Saltillo Coahuila, 25280, México https://orcid.org/0000-0003-1873-024X
  • Miguel Velazquez-Manzanares Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila. Blvd. V. Carranza s/n, Saltillo Coahuila, 25280, México https://orcid.org/0000-0002-5125-1040

DOI:

https://doi.org/10.5599/jese.3630

Keywords:

Thienobenzodiazepine derivative, immiscible electrolyte solutions (ITIES), voltammetry techniques, ion transfer, ionic partition coefficient, Galvani transfer potential

Abstract

This study investigates the electrochemical transfer of olanzapine (OLP) across the interface between two immiscible electrolyte solutions using a water/1,2-dichloroethane system. Electrochemical experiments were performed using cyclic voltammetry, square-wave voltammetry analysis using a four-electrode electrochemical cell. The results revealed a reversible ion-transfer process of the protonated species OLPH⁺, with a half-wave transfer potential of 0.184 V on the Galvani potential scale. Voltammetric analysis demonstrated that the ion-transfer process was diffusion-controlled, as evidenced by the linear dependence of the peak current on both the square root of the scan rate and the OLP concentration. Based on the experimental data, the formal Gibbs energy of transfer was determined to be 17.75 kJ mol⁻¹, and the ionic partition coefficient was calculated to be -3.11, indicating the semihydrophobic character of the drug. Furthermore, capacitance studies showed that the breakdown of the electrical double layer occurs at the same transfer potential as that determined by voltammetric techniques, confirming the faradaic nature of the ion-transfer process.

 

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References

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Published

10-10-2026

Issue

Vol. 16 (2026)

Section

Physical electrochemistry

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Copyright (c) 2026 Renata Ailen Rodríguez Paz, Luis Gonzalo López-Martínez, Judith Amador-Hernández , Miguel Velazquez-Manzanares

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Electrochemical study of olanzapine transfer across the water/1,2-dichloroethane interface: Original scientific paper. (2026). Journal of Electrochemical Science and Engineering, 16, Article 3630. https://doi.org/10.5599/jese.3630

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