Highly sensitive voltammetric nanosensor based on Cu2O nanocubes modified screen-printed carbon electrode for determination of 4-aminophenol

Original scientific paper

Authors

DOI:

https://doi.org/10.5599/jese.3257

Keywords:

Phenol derivative, electrochemical detection, nano copper oxide, real water samples, modified carbon electrode

Abstract

X-ray diffraction was used in this work to analyse the Cu2O nanocubes prepared via one-pot wet-chemical method. Next, 4-aminophenol (4-AP) was determined using a Cu2O nanocube-modified screen-printed carbon electrode (Cu2O/SPCE). Chronoampero­metry, differen­tial pulse voltammetry, and cyclic voltammetry were used to assess the electrochemical characteristics of 4-AP at the Cu2O/SPCE sensor. As the redox peak currents increased, the results showed that the Cu2O/SPCE exhibited strong electrocatalytic activity for 4-AP. With a limit of detection of 0.008 μM, the oxidation peak current under the chosen cir­cum­stances was proportional to the 4-AP in the range of 0.02 to 500.0 μM. With positive outcomes, the suggested approach was used to ascertain the 4-AP content of actual samples.

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References

[1] H. Yin, Q. Ma, Y. Zhou, S. Ai, L. Zhu, Electrochemical behavior and voltammetric determination of 4-aminophenol based on graphene–chitosan composite film modified glassy carbon electrode, Electrochimica Acta 55 (2010) 7102-7108. https://doi.org/10.1016/j.electacta.2010.06.072 DOI: https://doi.org/10.1016/j.electacta.2010.06.072

[2] M. Tohidinia, A. Biabangard, M. Noroozifar, Platinized Agarose microspheres as a new modifier in graphite paste electrodes for the electrochemical determination of 4-aminophenol, RSC Advances 10 (2020) 2944-2951. https://doi.org/10.1039/C9RA08629C DOI: https://doi.org/10.1039/C9RA08629C

[3] R. C. Harmon, K. K. Kiningham, M.A. Valentovic, Pyruvate reduces 4-aminophenol in vitro toxicity, Toxicology and Applied Pharmacology 213 (2006) 179-186. https://doi.org/10.1016/j.taap.2005.10.008 DOI: https://doi.org/10.1016/j.taap.2005.10.008

[4] H. Zhang, Z. Xing, M. Pan, H. B. Wang, Y. M. Liu, Highly sensitive and selective electrochemical determination of 4-aminophenol based on flower-like Ag-Au nanocomposites modified glassy carbon electrode, Journal of The Electrochemical Society 167 (2020) 126504. DOI 10.1149/1945-7111/abae91 DOI: https://doi.org/10.1149/1945-7111/abae91

[5] M. Nemakal, S. Aralekallu, I. Mohammed, M. Pari, K. V. Reddy, L. K. Sannegowda, Nanomolar detection of 4-aminophenol using amperometric sensor based on a novel phthalocyanine, Electrochimica Acta 318 (2019) 342-353. https://doi.org/10.1016/j.electacta.2019.06.097 DOI: https://doi.org/10.1016/j.electacta.2019.06.097

[6] T. T. Calam, G. T. Çakıcı, A sensitive method for the determination of 4-aminophenol using an electrochemical sensor based on 5-amino-1, 3, 4-thiadiazole-2-thiol, Journal of Food Composition and Analysis 114 (2022) 104728. https://doi.org/10.1016/j.jfca.2022.104728 DOI: https://doi.org/10.1016/j.jfca.2022.104728

[7] J. Ahmed, R. H. Rakib, M. M. Rahman, A. M. Asiri, I. A. Siddiquey, S. S. Islam, M. A. Hasnat, Electrocatalytic oxidation of 4-aminophenol molecules at the surface of an FeS2/carbon nanotube modified glassy carbon electrode in aqueous medium, ChemPlusChem 84 (2019) 175-182. https://doi.org/10.1002/cplu.201800660 DOI: https://doi.org/10.1002/cplu.201800660

[8] Q. Chu, L. Jiang, X. Tian, J. Ye, Rapid determination of acetaminophen and p-aminophenol in pharmaceutical formulations using miniaturized capillary electrophoresis with amperometric detection, Analytica Chimica Acta 606 (2008) 246-251. https://doi.org/10.1016/j.aca.2007.11.015 DOI: https://doi.org/10.1016/j.aca.2007.11.015

[9] M. S. Mustafa, N. N. Mohammad, F. H. Radha, K. F. Kayani, H. O. Ghareeb, S. J. Mohammed, Eco-friendly spectrophotometric methods for concurrent analysis of phenol, 2-aminophenol, and 4-aminophenol in ternary mixtures and water samples: assessment of environmental sustainability, RSC Advances 14 (2024) 16045-16055. https://doi.org/10.1039/D4RA01094A DOI: https://doi.org/10.1039/D4RA01094A

[10] E. Wyszecka-Kaszuba, M. Warowna-Grześkiewicz, Z. Fijałek, Determination of 4-aminophenol impurities in multicomponent analgesic preparations by HPLC with amperometric detection, Journal of Pharmaceutical and Biomedical Analysis 32 (2003) 1081-1086. https://doi.org/10.1016/S0731-7085(03)00212-7 DOI: https://doi.org/10.1016/S0731-7085(03)00212-7

[11] D. Wu, Y. Wang, W. Qi, J. Xu, K. Pei, L. Ma, L. Qi, Long-lasting chemiluminescence of lucigenin/p-aminophenol system for detection of p-aminophenol in environmental water, Dyes and Pigments 223 (2024) 111959. https://doi.org/10.1016/j.dyepig.2024.111959 DOI: https://doi.org/10.1016/j.dyepig.2024.111959

[12] B. Dejaegher, M. S. Bloomfield, J. Smeyers-Verbeke, Y. Vander Heyden, Validation of a fluorimetric assay for 4-aminophenol in paracetamol formulations, Talanta 75 (2008) 258-265. https://doi.org/10.1016/j.talanta.2007.11.029 DOI: https://doi.org/10.1016/j.talanta.2007.11.029

[13] R. D. Crapnell, C. E. Banks, Electroanalytical overview: screen-printed electrochemical sensing platforms, ChemElectroChem 11 (2024) e202400370. https://doi.org/10.1002/celc.202400370 DOI: https://doi.org/10.1002/celc.202400370

[14] M. C. Blanco-López, M. J. Lobo-Castanon, A. J. Miranda-Ordieres, P. Tuñón-Blanco, Voltammetric sensor for vanillylmandelic acid based on molecularly imprinted polymer-modified electrodes, Biosensors and Bioelectronics 18 (2003) 353-362. https://doi.org/10.1016/S0956-5663(02)00151-3 DOI: https://doi.org/10.1016/S0956-5663(02)00151-3

[15] A. B. Monnappa, J. G. Manjunatha, A. S. Bhatt, Design of a sensitive and selective voltammetric sensor based on a cationic surfactant-modified carbon paste electrode for the determination of alloxan, ACS Omega 5 (2020) 23481-23490. https://doi.org/10.1021/acsomega.0c03517 DOI: https://doi.org/10.1021/acsomega.0c03517

[16] Z. Sarbandian, H. Beitollahi, An electrochemical sensor based on a modified glassy carbon electrode for detection of epinephrine in the presence of theophylline, ADMET and DMPK 12(2) (2024) 391-402. https://doi.org/10.5599/admet.2082 DOI: https://doi.org/10.5599/admet.2082

[17] V. Q. Khue, T. Q. Huy, V. N. Phan, A. Tuan-Le, D. T. T. Le, M. Tonezzer, N. T. H. Hanh, Electrochemical stability of screen-printed electrodes modified with Au nanoparticles for detection of methicillin-resistant Staphylococcus aureus, Materials Chemistry and Physics 255 (2020) 123562. https://doi.org/10.1016/j.matchemphys.2020.123562 DOI: https://doi.org/10.1016/j.matchemphys.2020.123562

[18] Q. K. Vu, Q. H. Tran, N. P. Vu, T. L. Anh, T. T. Le Dang, T. Matteo, T. H. H. Nguyen, A label-free electrochemical biosensor based on screen-printed electrodes modified with gold nanoparticles for quick detection of bacterial pathogens, Materials Today Communications 26 (2021) 101726. https://doi.org/10.1016/j.mtcomm.2020.101726 DOI: https://doi.org/10.1016/j.mtcomm.2020.101726

[19] M. Li, D. W. Li, G. Xiu, Y. T. Long, Applications of screen-printed electrodes in current environmental analysis, Current Opinion in Electrochemistry 3 (2017) 137-143. https://doi.org/10.1016/j.coelec.2017.08.016 DOI: https://doi.org/10.1016/j.coelec.2017.08.016

[20] M. Amatatongchai, J. Sitanurak, W. Sroysee, S. Sodanat, S. Chairam, P. Jarujamrus, P. A. Lieberzeit, Highly sensitive and selective electrochemical paper-based device using a graphite screen-printed electrode modified with molecularly imprinted polymers coated Fe3O4@ Au@ SiO2 for serotonin determination, Analytica Chimica Acta 1077 (2019) 255-265. https://doi.org/10.1016/j.aca.2019.05.047 DOI: https://doi.org/10.1016/j.aca.2019.05.047

[21] R. Porada, K. Fendrych, B. Ba, Development of novel Mn-zeolite/graphite modified Screen-printed Carbon Electrode for ultrasensitive and selective determination of folic acid, Measurement 179 (2021) 109450. https://doi.org/10.1016/j.measurement.2021.109450 DOI: https://doi.org/10.1016/j.measurement.2021.109450

[22] S. Zhang, P. Ling, Y. Chen, J. Liu, C. Yang, 2D/2D porous Co3O4/rGO nanosheets act as an electrochemical sensor for voltammetric tryptophan detection, Diamond and Related Materials 135 (2023) 109811. https://doi.org/10.1016/j.diamond.2023.109811 DOI: https://doi.org/10.1016/j.diamond.2023.109811

[23] J. M. Alshawi, M. Q. Mohammed, H. F. Alesary, H. K. Ismail, S. Barton, Voltammetric determination of Hg2+, Zn2+, and Pb2+ ions using a PEDOT/NTA-modified electrode, ACS Omega 7 (2022) 20405-20419. https://doi.org/10.1021/acsomega.2c02682 DOI: https://doi.org/10.1021/acsomega.2c02682

[24] M. Harsini, B. A. Widyaningrum, E. Fitriany, D. R. A. Paramita, A. N. Farida, A. Baktir, S. C. W. Sakti, Electrochemical synthesis of polymelamine/gold nanoparticle modified carbon paste electrode as voltammetric sensor of dopamine, Chinese Journal of Analytical Chemistry 50 (2022) 100052. https://doi.org/10.1016/j.cjac.2022.100052 DOI: https://doi.org/10.1016/j.cjac.2022.100052

[25] M. Kumar, B. K. Swamy, C. Sravanthi, C. P. Kumar, G. K. Jayaprakash, NiFe2O4 nanoparticle modified electrochemical sensor for the voltammetric study of folic acid and paracetamol, Materials Chemistry and Physics 284 (2022) 126087. https://doi.org/10.1016/j.matchemphys.2022.126087 DOI: https://doi.org/10.1016/j.matchemphys.2022.126087

[26] A.U. Ibrahim, P.C. Pwavodi, M. Ozsoz, B.B. Duwa, I. Irkham, Y.W. Hartati, Nano-modified biosensors for detection of pathogenic diseases: The prospect of smart, multiplex and point-of-care testing, ADMET & DMPK 13 (2025) 2799. https://doi.org/10.5599/admet.2799 DOI: https://doi.org/10.5599/admet.2799

[27] T. Zhou, Q. Wang, A. Umar, F. Xu, Y. Gao, J. Wu, Z. Guo, Electrochemical sensors based on semiconductor nanostructures modified electrodes, Science of Advanced Materials 7 (2015) 2069-2083. https://doi.org/10.1166/sam.2015.2437 DOI: https://doi.org/10.1166/sam.2015.2437

[28] R. Abdel-Karim, Y. Reda, A. Abdel-Fattah, Nanostructured materials-based nanosensors, Journal of the Electrochemical Society 167 (2020) 037554. https://doi.org/10.1149/1945-7111/ab67aa DOI: https://doi.org/10.1149/1945-7111/ab67aa

[29] Y. Sun, X. Wang, H. Zhang, Sensitive and stable electrochemical sensor for folic acid determination using a ZIF-67/AgNWs nanocomposite, Biosensors 12 (2022) 382-394. https://doi.org/10.3390/bios12060382 DOI: https://doi.org/10.3390/bios12060382

[30] N. M. Noah, Design and synthesis of nanostructured materials for sensor applications, Journal of Nanomaterials 2020 (2020) 8855321. https://doi.org/10.1155/2020/8855321 DOI: https://doi.org/10.1155/2020/8855321

[31] M. Chaudhary, A. Kumar, A. Devi, B. P. Singh, B. D. Malhotra, K. Singhal, R. Singhal, Prospects of nanostructure-based electrochemical sensors for drug detection: a review, Materials Advances 4 (2023) 432-457. https://doi.org/10.1039/D2MA00896C DOI: https://doi.org/10.1039/D2MA00896C

[32] Y. Jia, N. Shang, X. He, A. Nsabimana, Y. Gao, J. Ju, Y. Zhang, Electrocatalytically active cuprous oxide nanocubes anchored onto macroporous carbon composite for hydrazine detection, Journal of Colloid and Interface Science 606 (2022) 1239-1248. https://doi.org/10.1016/j.jcis.2021.08.154 DOI: https://doi.org/10.1016/j.jcis.2021.08.154

[33] M. Etzi, A. Mezza, V. Bugliarelli, J. Dangbegnon, D. Sassone, M. Bartoli, J. Zeng, A. Chiodoni, S. Bocchini, A. Sacco, C. F. Pirri, Size-Dependent Selectivity of Cu2O Nanocube Catalysts for CO2 Reduction at Industrial Current Densities, Electrochimica Acta 551 (2026) 148114. https://doi.org/10.1016/j.electacta.2026.148114 DOI: https://doi.org/10.1016/j.electacta.2026.148114

[34] S. Dong, S. Zhang, L. Chi, P. He, Q. Wang, Y. Fang, Electrochemical behaviors of amino acids at multiwall carbon nanotubes and Cu2O modified carbon paste electrode, Analytical Biochemistry 381 (2008) 199-204. https://doi.org/10.1016/j.ab.2008.05.011 DOI: https://doi.org/10.1016/j.ab.2008.05.011

[35] S. Felix, P. Kollu, B. P. Raghupathy, S. Kwan Jeong, A. Nirmala Grace, Electrocatalytic activity of Cu2O nanocubes based electrode for glucose oxidation, Journal of Chemical Sciences 126 (2014) 25-32. https://doi.org/10.1007/s12039-013-0564-x DOI: https://doi.org/10.1007/s12039-013-0564-x

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Published

30-06-2026

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Electroanalytical chemistry

How to Cite

Highly sensitive voltammetric nanosensor based on Cu2O nanocubes modified screen-printed carbon electrode for determination of 4-aminophenol: Original scientific paper. (2026). Journal of Electrochemical Science and Engineering, 16, Article 3257. https://doi.org/10.5599/jese.3257