Simultaneous electrochemical determination of acetaminophen and metoclopramide at electrochemically pre-treated disposable graphite pencil electrode
DOI:
https://doi.org/10.5599/jese.308Keywords:
Acetaminophen, Metoclopramide, Voltammetry, Graphite Pencil electrode, Analytical applicationsAbstract
A sensitive and economic voltammetric method was developed for the simultaneous determination of acetaminophen (AMP) and metoclopramide (MCP) using pre-treated graphite pencil electrode (PTGPE). Compared to a graphite pencil electrode, the pre-treated electrode showed an apparent shift of the oxidation potentials in the positive direction and a notable enhancement in the current responses for both AMP and MCP. Cyclic voltammetry (CV) was used to study the voltammetric behavior of the drugs, while differential pulse voltammetry (DPV) was used to determine AMP and MCP simultaneously. The dependence of the current on scan rate, pH and concentration was investigated to boost the experimental conditions for simultaneous determination. The calibration curves were obtained over the range of 0.1×10-7 to 1.1×10-7 M, the concentration of each of both the drugs was varied by keeping the other constant, and achieved lower detection limit of 3.25 nM for AMP and 1.16 nM for MCP. The developed method was found to be selective and rapid for the simultaneous determination of AMP and MCP. The proposed method was applied simultaneously in real samples and pharmaceutical samples, with satisfactory results.
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