NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties

Mire Zloh

doi:10.5599/admet.737

Authors

Mire Zloh 1) UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London, WC1N 1AX, UK 2)Faculty of Pharmacy, University Business Academy, Trg mladenaca 5, 21000, Novi Sad, Serbia http://orcid.org/0000-0002-4848-2737

DOI:

https://doi.org/10.5599/admet.737

Keywords:

logP, qNMR, drug solubility, DOSY, pharmaceutical formulations.

Abstract

Determination of physico-chemical properties of compounds is one of the corner-stones in selection of hit molecules for further progression into lead development in the modern drug discovery process. The speed of traditional analyses and limited quantities of hit molecules are obstacles for efficient acquisition of experimental data. Herein, the range of applications of quantitative nuclear magnetic resonance (NMR) spectroscopy as a fast technique used to evaluate solubility, log P and pKa are discussed.