Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers

Abstract

The paper is devoted to the study of the ion exchange encapsulation of nicotinic acid in nanocontainers on polymer matrices. Dowex-50 cation exchanger, sulphonated polymer based on metacyclophanoctol, polymer zirconium phosphate, and strongly basic Dowex-1 anion exchanger are used as polymer matrices. It was confirmed that commercial ion exchangers can encapsulate up to 0.64 g of nicotinic acid per gram of polymer. The high elution rate of nicotinic acid from nanocontainers via the ion exchange mechanism makes it possible to achieve the desired pharmacokinetics of drug release in vivo.