Voltammetric determination of sumatriptan in the presence of naproxen using a modified screen printed electrode: Original scientific article

Hazim Saad  Jabbar Al-Maliki; Sudad Jasim Mohammed; Adil  Turki Al-Musawi; Aliaa Saadoon Abdul- Razaq  Al-Faraji; Mazin Hadi Kzar; Abdul Amir H. Kadhum; Huda Hadi Nameh; Raed Muslim Mhaibes

doi:10.5599/admet.2635

Authors

Hazim Saad Jabbar Al-Maliki Department of Basic Sciences, College of Dentistry, University of Basrah, Iraq https://orcid.org/0000-0003-0779-2023
Sudad Jasim Mohammed Market Research and Consumer Protection Center, University of Baghdad, Iraq https://orcid.org/0000-0002-1750-0576
Adil Turki Al-Musawi Market Research and Consumer Protection Center, University of Baghdad, Iraq https://orcid.org/0000-0002-1309-4654
Aliaa Saadoon Abdul- Razaq Al-Faraji Market Research and Consumer Protection Center, University of Baghdad, Iraq https://orcid.org/0009-0008-6429-4534
Mazin Hadi Kzar College of Physical Education and Sport Sciences, Al-Mustaqbal University, 51001 Hillah, Babil-Iraq https://orcid.org/0000-0001-8341-6842
Abdul Amir H. Kadhum College of Medicine, University of Al-Ameed, Karbala, Iraq https://orcid.org/0000-0003-4074-9123
Huda Hadi Nameh College of Pharmacy, University of Hilla, Babylon, Iraq https://orcid.org/0009-0007-5584-3733
Raed Muslim Mhaibes Department of Biochemistry, College of Medicine Massan University,Missan Iraq

DOI:

https://doi.org/10.5599/admet.2635

Keywords:

Simultaneous determination, real sample analysis, nanomaterials, drug analysis

Abstract

Background and purpose: Sumatriptan is used to alleviate symptoms of migraine headaches, particularly during acute attacks. Naproxen is a medication that provides relief from pain, inflammation, and fever. Therefore, determination of them is important. Experimental approach: In the present work, CoMoO₄ nanos¬heets were synthesized in a basic and easy way. A screen-printed graphite electrode's surface was altered using the as-prepared CoMoO₄ nanosheets' high electroactivity to create a CoMoO₄ nanosheets-modified screen-printed electrode (CoMoO₄ NSs-SPE), which was then employed for sumatriptan's electrochemical oxidation. Due to the superior electron transfer characteristics and catalytic activity of the produced CoMoO₄ nanosheets, the results demonstrated a notable improvement in sumatriptan's current responses. This study examined the electrochemical behavior of sumatriptan on the CoMoO₄ NSs-SPE utilizing a number of methods, including as chronoamperometry, cyclic voltammetry, and differential pulse voltammetry (DPV). Key results: With a high sensitivity of 0.0718 μA/μM and a good correlation value of 0.9998, a linear calibration curve was obtained over a broad concentration range of 0.02-600.0 μM, suggesting a strong linear connection between the concentration and the response. Based on a signal-to-noise ratio of 3, the limit of detection for sumatriptan was determined to be 0.01 μM, suggesting a high degree of sensitivity for the detection technique. DPV results showed that the CoMoO4 nanosheets-modified screen-printed electrode (CoMoO4 NSs-SPE) could detect naproxen and sumatriptan at the same time. Conclusion: The created sensor's usefulness and efficacy in real-world applications were demonstrated when it was successfully used to identify the target analytes in actual samples.

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