Investigating antimicrobial features and drug interactions of sedoanalgesics in intensive care unit: an experimental study

  • Ozge Unlu Istanbul Atlas University, Faculty of Medicine, Department of Medical Microbiology, Turkey https://orcid.org/0000-0002-5411-5925
  • Emre Bingul Recep Tayyip Erdogan University, Training and Research Hospital, Department of Anesthesiology and Reanimation, Turkey https://orcid.org/0000-0002-8662-5380
  • Sevgi Kesi̇ci̇ Health Sciences University, Hamidiye Etfal Training and Research Hospital, Depatment of Anesthesiology, Istanbul, Turkey https://orcid.org/0000-0002-8276-6039
  • Mehmet Demirci Kirklareli University, Faculty of Medicine, Department of Medical Microbiology, Turkey https://orcid.org/0000-0001-9670-2426
drug interactions of sedoanalgesics

Abstract

Study Objective: Aim of this study was to evaluate antimicrobial effects and interaction between analgesic combinations of fentanyl citrate, dexmedetomidine hydrochloride and tramadol hydrochloride on Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Candida albicans which are some of the most common nosocomial infection related microorganisms. Design: In vitro prospective study. Setting: University Clinical Microbiology Laboratory. Measurements: In order to evaluate in vitro antimicrobial effects and interaction between analgesic combinations, tramadol hydrochloride, fentanyl citrate and dexmedetomidin were used against S. aureus ATCC 29213, K. pneumoniae, E. coli ATCC 25922, P. aeruginosa ATCC 27853 and C. albicans ATCC 10231 standard strains by microdilution method. Main Results: According to microdilution assays tramadol has shown the most efficient antimicrobial activity also it has been observed that 10 mg/ml concentrated dexmedetomidine has antimicrobial effects on S. aureus, K. pneumoniae and P. aeruginosa. Fentanyl has displayed evident inhibitory potency on the pathogens except for Klebsiella pneumoniae, nevertheless our predefined minimum concentration inhibited growth by 9.5 %. Fentanyl and dexmedetomidine together exhibited more antimicrobial effect on P. aeruginosa and E. coli growth. Additionally, when the three drugs examined together, microbial inhibition occurred more than expected on E. coli again and also on C. albicans growth. Conclusions: Our results revealed the antimicrobial properties and synergy with the different combinations of fentanyl, dexmedetomidine and tramadol against the most common nosocomial infection agents in the ICU. This is the first study in the literature looking into the microbial “interactions” of opioids and sedative drugs but more research is needed in order to define clinico-laboratory correlation.

©2021 by the authors. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Published
06-09-2021
Section
Original Scientific Articles