Lost in modelling and simulation?

Authors

DOI:

https://doi.org/10.5599/admet.923
physiologically-based pharmacokinetic modelling (PBPK)

Abstract

Over the past few decades, physiologically-based pharmacokinetic modelling (PBPK) has been anticipated to be a powerful tool to improve the productivity of drug discovery and development. However, recently, multiple systematic evaluation studies independently suggested that the predictive power of current oral absorption (OA) PBPK models needs significant improvement. There is some disagreement between the industry and regulators about the credibility of OA PBPK modelling. Recently, the editorial board of AMDET&DMPK has announced the policy for the articles related to PBPK modelling (Modelling and simulation ethics). In this feature article, the background of this policy is explained: (1) Requirements for scientific writing of PBPK modelling, (2) Scientific literacy for PBPK modelling, and (3) Middle-out approaches. PBPK models are a useful tool if used correctly. This article will hopefully help advance the science of OA PBPK models. 

Downloads

Download data is not yet available.

Published

20-03-2021

How to Cite

Sugano, K. (2021). Lost in modelling and simulation?. ADMET and DMPK, 9(2), 75–109. https://doi.org/10.5599/admet.923

Issue

Section

Featured articles

Most read articles by the same author(s)