Dissolution of an ensemble of differently shaped poly-dispersed drug particles undergoing solubility reduction: mathematical modelling

  • Michela Abrami Trieste University Department of Engineering and Architecture
  • Lucia Grassi Liceo Scientifico Galileo Galilei
  • Rosario Di Vittorio University of Trieste Department of Engineering and Architecture
  • Dritan Hasa University of Trieste Depatment of Chemical and Pharmaceutical Sciences
  • Beatrice Perissutti University of Trieste Depatment of Chemical and Pharmaceutical Sciences
  • Dario Voinovich University of Trieste Depatment of Chemical and Pharmaceutical Sciences
  • Gabriele Grassi University of Trieste Dept. of Life Sciences, Cattinara University Hospital
  • Italo Colombo University of Trieste Department of Engineering and Architecture
  • Mario Grassi Trieste University - Department of Engineering and Architercture http://orcid.org/0000-0002-3532-3200
Dissolution of an ensemble of differently shaped poly-dispersed drug particles undergoing solubility reduction: mathematical modelling

Abstract

The aim of this theoretical paper is to develop a mathematical model for describing the dissolution process, in a finite liquid environment, of an ensemble of poly-dispersed drug particles, in form of sphere, cylinder and parallelepiped that can undergo solubility reduction due to phase transition induced by dissolution. The main result of this work consists in its simplicity as, whatever the particular particles size distribution, only two ordinary differential equations are needed to describe the dissolution process. This, in turn, reflects in a very powerful and agile theoretical tool that can be easily implemented in electronic sheets, a widespread tool among the research community. Another model advantage lies on the possibility of determining its parameters by means of common independent techniques thus enabling the evaluation of the importance of solid wettability on the dissolution process.

Downloads

Download data is not yet available.
Published
14-07-2020
Section
Solubility special issue