Bioenhancing effects of naringin on atrovastatin

Authors

  • Sama Venkatesh G. Pulla Reddy College of Pharmacy, Mehdipatnam, Mehdipatnam, Hyderabad- 500028, India
  • Balaraju Pagilla G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
  • Rajeswari Chiluka G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
  • Ravi Alvala G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
  • Ravi Kumar Pola G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500028, India
  • Ramesh Mullangi JubilantBiosys, Industrial Suburb, Yeshwanthpur, Bangalore-566022, India

DOI:

https://doi.org/10.5599/admet.647

Keywords:

Naringin, Bioenhancer, Atorvastatin, Tyloxapol, Plasma concentrations, RP-HPLC.

Abstract

Naringin (CAS no: 10236-47-2) is a flavonone glycoside obtained from Citrus paradisi (grapefruit), a natural bioenhancer and reported to enhance the bioavailability of drugs by inhibiting cytochrome P450 and P-glycoprotein (P-gp). The aim of the present study was to investigate the effect of naringin on antihyperlipidemic properties of atorvastatin (AST) in tyloxapol induced hyperlipidemic rats and the effects were supported with measurement of plasma concentrations of AST by HPLC method. Animals received AST along with naringin (15 and 30 mg/kg) shown higher percent reduction in both cholesterol and triglycerides levels, when compared to animals received AST alone at dose of 25 and 50 mg/kg and it was found that the higher percent reduction in cholesterol and triglycerides was proportional to increase in plasma concentration of AST. From the results it is evident that the co-administration of naringin along with AST increased the plasma concentration of AST. The findings of the present study confirmed that naringin could be used as bioenhancer. The co-administration of AST and the diet with naringin (grapefruit) to the patients may potentiate the therapeutic efficacy of AST.

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Published

04-08-2019

How to Cite

Venkatesh, S., Pagilla, B., Chiluka, R., Alvala, R., Pola, R. K., & Mullangi, R. (2019). Bioenhancing effects of naringin on atrovastatin. ADMET and DMPK, 7(3), 174–182. https://doi.org/10.5599/admet.647

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Section

Original Scientific Articles

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