ADME-Tox profiling of some low molecular weight water soluble chitosan derivatives

  • Adriana Isvoran West University of TimiÈ™oara http://orcid.org/0000-0002-3068-2642
  • Alecu Aurel Ciorsac University Politehnica TimiÈ™oara
  • Vasile Ostafe West University of TimiÈ™oara

Abstract

Within this study we use a few computational tools for predicting absorption, distribution, metabolism, excretion and toxicity (ADME-Tox), pharmacokinetics profiles, toxic/adverse effects, carcinogenicity, cardiotoxicity and endocrine disruption of some of low molecular weight water soluble derivatives of chitosan that are used in wound healing. Investigated compounds do not possess drug-like properties, their pharmacokinetics profiles reveal poor gastrointestinal absorption and low skin penetration. Chitosan derivatives cannot pass the blood-brain barrier and they are not able to inhibit the enzymes of the cytochrome P450 that are involved in the metabolism of xenobiotics. They do not reflect carcinogenicity and cardiotoxicity and reveal only a low probability to be endocrine disruptors. The main side effects in humans of the investigated compounds are: weight loss, acidosis, gastrointestinal toxicity, respiratory failure. This information is especially important for professional exposure and accidental contamination with these compounds.

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Published
29-09-2017
Section
Original Scientific Articles