The intrinsic aqueous solubility of indomethacin

  • John Comer Sirius Analytical Ltd.
  • Sam Judge
  • Darren Matthews
  • Louise Towers
  • Bruno Falcone
  • Jonathan Goodman
  • John Dearden


A value of 8.8 μg/mL was measured for the intrinsic solubility of indomethacin. Evidence of an amorphous form with a solubility of about 77 μg/mL was also obtained. Solubility measurements were conducted using the CheqSol and Curve Fitting methods using a maximum pH of 9. It is also demonstrated that a published intrinsic solubility of 410 μg/mL was in error due to decomposition of indomethacin at pH 12. The decomposition of indomethacin at pH 12 was investigated. Decomposition products comprising p-chlorobenzoic acid and 5-Methoxy-2-methyl-3-indoleacetic acid were isolated and characterised.


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