Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules

  • Natalia Loginova Faculty of Chemistry, Belarusian State University, Minsk, Belarus https://orcid.org/0000-0003-0531-3594
  • Maxim Gvozdev Faculty of Chemistry, Belarusian State University, Minsk, Belarus https://orcid.org/0000-0002-4504-2090
  • Nikolai Osipovich Research Institute for Physico-Chemical Problems of the Belarusian State University, Minsk, Belarus https://orcid.org/0000-0001-6354-5292
  • Alina Khodosovskaya Faculty of Biology, Belarusian State University, Minsk, Belarus https://orcid.org/0000-0002-4987-7079
  • Tatiana Koval’chuk-Rabchinskaya Faculty of Chemistry, Belarusian State University, Minsk, Belarus
  • Galina Ksendzova Research Institute for Physico-Chemical Problems of the Belarusian State University, Minsk, Belarus
  • Dzmitry Kotsikau Faculty of Chemistry, Belarusian State University, Minsk, Belarus https://orcid.org/0000-0002-3318-7620
  • Anatoly Evtushenkov Faculty of Biology, Belarusian State University, Minsk, Belarus
Silver(I) complexes with phenolic Schiff bases

Abstract

Novel Ag(I) complexes (2a2c) with phenolic Schiff bases were synthesized using 4,6-di-tert-butyl-3-(((5-mercapto-1,3,4-thiadiazol-2-yl)imino)methyl)benzene-1,2-diol (1a), 4,6-di-tert-butyl-3-(((4-mercaptophe­nyl­)­imino)­methyl)benzene-1,2-diol (1b), and 4,6-di-tert-butyl-3-(((3-mercaptophenyl)imino)methyl)­benzene-1,2-diol (1c). They were examined by elemental analysis, FT-IR, UV-Vis, 1H-NMR spectroscopy, XRD, cyclic voltammetry, conductivity measurements, and biological methods. The complexes are characterized by distorted geometry of the coordination cores AgN2S2 (2c), AgNS (2b) and AgS2 (2a). These stable complexes were not typified by the intramolecular redox reaction in organic solvents resulting in the formation of silver nanoparticles (AgNPs). Antibacterial activity of 1a1c and 2a2c was evaluated in comparison with AgNPs and commonly used antibiotics. All the complexes were more active than the ligands against the bacteria tested (14), but they were less active than AgNPs and commonly used antibiotics. Both 1a1c and their complexes 2a2c exhibited the capability for the bovine heart Fe(III)-Cyt c reduction. The ligands 1b and 1c were characterized by the highest reduction rate among the compounds under study, and they showed a higher reducing ability (determined by cyclic voltammetry) as compared with that of their Ag(I) complexes 2b and 2c.

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Published
18-03-2022
Section
Original Scientific Articles