Electroanalytical methods in the analysis of drugs and metabolites


Special issue guest-edited by Hadi Beitollahi

Pharmacokinetics is concerned with the fate of a drug in the organism from its administration, followed by its distribution, metabolism and excretion (ADME). Accurate, fast and reliable analytical methods are prerequisites for the precise determination of pharmacokinetic parameters and for supporting drug discovery and development in the various stages of pharmaceutical research. Analysis of biological matrices is required to assist in understanding specific pathways of drugs and their metabolism.

The most frequently used analytical method in pharma research is liquid chromatography with mass spectrometry or UV detection. While it is used routinely in various laboratories, it sometimes demands developing and validating complex methods. In addition, they might be time-consuming and require trained personnel. On the other hand, electroanalytical methods have proven useful in the analytical determination of many analytes, including those in biological and food samples. Electroanalytical methods are fast, simple, accurate and very sensitive. Today, they can reliably determine the analyte concentration is nano- and sub-nano concentration in various matrices. Depending on the electrode preparations and electrocatalytic preparation of electrode materials, interferences can be eliminated and a high signal-to-noise ratio achieved.

This special issue of ADMET and DMPK aims to give an overview of the state-of-the-art technologies and advanced methodologies in the electrochemical analysis of drugs and metabolites, including the development of novel electrodes and electrocatalysts. Also, other aspects of electrochemical analysis, such as new methodologies for coulometric or amperometric detection in HPLC, are also covered. The special issue is guest-edited by Hadi Beitolahi, Graduate University of Advanced Technology, Kerman, Iran. It is planned for March 2023 and the submission deadline is February 15, 2023. During submission, please select „Electroanalysis“ in the Section field.