Surfactant modified carbon nanotube paste electrode for the sensitive determination of mitoxantrone anticancer drug
DOI:
https://doi.org/10.5599/jese.368Keywords:
Electrochemical sensors, MTX determination, carbon nanotubes, surfactant modified electrodes
Abstract
Surfactant modified carbon nanotube paste electrode is prepared as electrochemical sensor with high sensitivity in responding to Mitoxantrone (MTX). Electrochemical oxidation of MTX is investigated in buffered solution by cyclic voltammetry that is found very sensitive method for detection of MTX. It is shown that the sodium dodecyl sulfate modified carbon nanotube paste electrode (SDSMCNTPE) gives enhanced current response for MTX compared to the bare carbon nanotube paste electrode (BCNTPE). Different parameters were tested to optimize the conditions for MTX determination. The effects of different surfactant and surfactant concentration, pH, scan rate, detection limit (LOD), limit of quantification (LOQ) and concentration of MTX on the oxidation peak current values were determined. Excellent results were obtained by cyclic voltammetry using SDSMCNTPE, where two MTX oxidation peaks appeared at 367 and 596 mV vs. SCE. Detailed analysis of the second voltammetric peak showed the linear dynamic range between 2×10−7 and 7×10−6 M MTX with the slope of co-relation coefficient of 0.99271. LOD and LOQ were determined as 3.5 ×10−8 M and 11×10−8 M, respectively. The SDSMCNTPE showed very good reproducibility, high stability in its voltammetric response, high electrochemical sensitivity and low detection limit for MTX.
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