Etoricoxib selective sensor based on uracil-5,6-diamino-2-thio hydrochloride as neutral carrier for potentiometric analysis in pharmaceutical preparations

Authors

  • Salwa Fares Rassi Department of Chemistry, Faculty of Science, Al-Baath University, Homs

DOI:

https://doi.org/10.5599/jese.284

Keywords:

Etoricoxib, Uracil-5, 6-diamino-2-thio hydrochloride, PVC membrane, Potentiometric method validation.

Abstract

A construction and electrochemical behavior of novel potentiometric membrane sensor responsive to the etoricoxib was described. The sensor was based on the ion-pair complex of etoricoxib (ET) with Uracil-5,6-diamino-2-thio hydrochloride UDTH (ET-UDTH) as exchange sites in a PVC matrix with different plasticizers dibutylphthalate (DBP) (electrode B) tri-n-butylphosphate (TBP) (electrode C), and dioctylphthalate (DOP) (electrode A). The electrodes exhibited near-Nernstian response for ET-UDTH over the concentration range 0.051-40.042 mM. The electrode offered significant advantages including long lifetime (about 2 months), excellent stability and reproducibility, good response time (10-25 s), and wide pH working range (pH 5-12). Selectivity coefficients of ET related to a number of interfering cation and some organic compounds were investigated, and there were negligible interference caused by most of the investigated species. The direct determination of 0.5-10 mM of ET showed an average recovery of 99.03-101.75% and a mean relative standard deviation 0.40-1.88. The results were obtained by determination of ET in tablets using the proposed electrodes which were comparable favorably with those obtained by spectrophotometric method

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References

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Published

09-06-2016

How to Cite

Rassi, S. F. (2016). Etoricoxib selective sensor based on uracil-5,6-diamino-2-thio hydrochloride as neutral carrier for potentiometric analysis in pharmaceutical preparations. Journal of Electrochemical Science and Engineering, 6(2), 187–198. https://doi.org/10.5599/jese.284

Issue

Section

Electrochemical Science