Corrosion inhibition effect of expired ibuprofen drug on copper in sulfuric acid solution

Original scientific paper


  • Said El Harrari Laboratory of Physical Chemistry of Materials, Faculty of Sciences Ben M’sick, Hassan II University of Casablanca, Morocco
  • Ayoub Salim Laboratory of Physical Chemistry of Materials, Faculty of Sciences Ben M’sick, Hassan II University of Casablanca, Morocco
  • Driss Takky Laboratory of Physical Chemistry of Materials, Faculty of Sciences Ben M’sick, Hassan II University of Casablanca, Morocco
  • Youssef Naimi Laboratory of Physical Chemistry of Materials, Faculty of Sciences Ben M’sick, Hassan II University of Casablanca, Morocco



Expired drugs, copper corrosion, inhibition efficiency, weight loss, electrochemical tests
Graphical Abstract


The application of copper as a material in various fields is widely recognized. However, in acidic environments, the electrical and mechanical properties of copper undergo negative alterations, resulting in its dissolution. To protect copper from degradation, the most effective approach is to employ inhibitors. Hence, in this paper, the expired ibuprofen drug has been investigated as a corrosion inhibitor for copper in 0.5 M H2SO4, employing weight loss and electrochemical tests. Compared with the pharmaceutical products used by other researchers in this field, the results showed that ibuprofen is highly effective in protecting copper from corrosion. It was noted that the inhibitory efficacy of ibuprofen increases with concentration. In addition, it was found that its adsorption follows Langmuir isotherm.


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Yu.I. Kuzntesov, I.A. Kuznetsov, N.P. Andreeva, Adsorbtion of sodium tridecanoate on copper from aqueous solutions and copper protection from atmospheric corrosion, The International Journal of Corrosion and Scale Inhibition 7 (2018) 650-658.

M. Finšgar, I. Milošev, Inhibition of copper corrosion by 1,2,3-benzotriazole: A review, Corrosion Science 52 (2010) 2737-2749.

S. Cao, R. Cheng, H. Liu, W. Shi, Q. Yuan, J. Chen, Comparative studies of three isatin-thi-osemicarbazones against corrosion of AA6060 aluminum alloy exposed to acidic NaCl medium, Journal of Molecular Structure 1269 (2022) 133835.

M. Galai, J. Ouassir, M. Ebn Touhami, H. Nassali, H. Benqlilou, T. Belhaj, K. Berrami, I. Mansouri, B. Oauki, α-Brass and (α+ β) Brass Degradation Processes in Azrou Soil Medium Used in Plumbing Devices, Journal of Bio-and Tribo-Corrosion 3 (2017) 30.

G. Tansuğ, T. Tüken, E.S. Giray, G. Fındıkkıran, G. Sığırcık, O. Demirkol, M. Erbil, A new corrosion inhibitor for copper protection, Corrosion Science 84 (2014) 21-29.

I.G. Akande, O.S.I. Fayomi, O.J. Adelakun, Evaluation of inhibitive performance of ibuprofen drug on copper in 0.5 M H2SO4, Case Studies in Chemical and Environmental Engineering 2 (2020) 100024.

V. Nemane, S. Chatterjee, Evaluation of microstructural, mechanical, and tribological charac¬teristics of Ni-B-W-SiC electroless composite coatings involving multi-pass scratch test, Materials Characterization 180 (2021) 111414.

H. Ma, S. Chen, B. Yin, S. Zhao, X. Liu, Impedance spectroscopic study of corrosion inhibition of copper by surfactants in the acidic solutions, Corrosion Science 45 (2003) 867-882.

A. Biswas, S. K. Das, P. Sahoo, Oxidation issues during heat treatment and effect on the tribo-mechanical performance of electroless Ni-P-Cu deposits, Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications 235 (2021) 1661-1685.

M. Fuseini, M. Mahmoud, Y. Zaghloul, M. F. Elkady, A. H. El-Shazly, Evaluation of synthesized polyaniline nanofibres as corrosion protection film coating on copper substrate by electrophoretic deposition, Journal of Materials Science 57 (2022) 6085-6101.

J.B. Matos, L.P. Pereira, S.M.L. Agostinho, O.E. Barcia, G.G.O. Cordeiro, E. D’Elia, Effect of cysteine on the anodic dissolution of copper in sulfuric acid medium, Journal of Electroanalytical Chemistry 570 (2004) 91-94.

A. Biswas, S. K. Das, P. Sahoo, Investigation of the tribological behavior of electroless Ni-W-P coating pre and post phase transformation regime, Materials Research Express 6 (2019) 0965c1.

J. Núñez-Morales, L. I. Jaramillo, P. J. Espinoza-Montero, V. E. Sánchez-Moreno, Evaluation of Adding Natural Gum to Pectin Extracted from Ecuadorian Citrus Peels as an Eco-Friendly Corrosion Inhibitor for Carbon Steel, Molecules 27 (2022) 2111.

L. Guo, I. B. Obot, X. Zheng, X. Shen, Y. Qiang, S. Kaya, C. Kaya, Theoretical insight into an empirical rule about organic corrosion inhibitors containing nitrogen, oxygen, and sulfur atoms, Applied Surface Science 406 (2017) 300-310.

S. C. Ikpeseni, G. O. Odu, H. I. Owamah, P. U. Onochie, D. C. Ukala, Thermodynamic parameters and adsorption mechanism of corrosion inhibition in mild steel using jatropha leaf extract in hydrochloric acid, Arabian Journal for Science and Engineering 46 (2021) 7789-779.

Z.Z. Tasić, M.B. Petrović Mihajlović, A.T. Simonović, M.B. Radovanović, M.M. Antonijević, ibuprofen as a corrosion inhibitor for copper in synthetic acid rain solution, Scientific Reports 9 (2019) 14710.

Y. Yu, D. Yang, D. Zhang, Y. Wang, L. Gao, Anti-corrosion film formed on HAl77-2 copper alloy surface by aliphatic polyamine in 3 wt.% NaCl solution, Applied Surface Science 392 (2017) 768-776.

Y. Gan, M. Zhou, C. Ji, G. Huang, Y. Chen, L. Li, T. Huang, Y. Lu, J. Lin, Tailoring the tribology property and corrosion resistance of selective laser melted CoCrMo alloys by varying copper content, Materials & Design 228 (2023) 111869.

R. Moaref, M. H. Shahini, H. E. Mohammadloo, B. Ramezanzadeh, S. Yazdani, Application of sustainable polymers for reinforcing bio-corrosion protection of magnesium implants–a review, Sustainable Chemistry and Pharmacy 29 (2022) 100780.

A. I. Abou-Sreea, M. H. Roby, H. A. Mahdy, N. M. Abdou, A. M. El-Tahan, M. T. El-Saadony, K. A. El-Tarabily, F. M. El-Saadony, Improvement of Selected Morphological, Physiological, and Biochemical Parameters of Roselle (Hibiscus sabdariffa L.) Grown under Different Salinity Levels Using Potassium Silicate and Aloe saponaria Extract, Plants 11 (2022) 497.

O. A. Elgyar, A. M. Ouf, A. El-Hossiany, A. S. Fouda, The inhibition action of viscum album extract on the corrosion of carbon steel in hydrochloric acid solution, Biointerface Research in Applied Chemistry 11 (2021) 14343-14350.

M. Finšgar, D. K. Merl, An electrochemical, long-term immersion, and XPS study of 2-mercaptobenzothiazole as a copper corrosion inhibitor in chloride solution, Corrosion Science 83 (2014) 164-175.

H. Cao, M. Fang, W. Jia, X. Liu, Q. Xu, Remarkable improvement of corrosion resistance of silane composite coating with Ti3C2Tx MXene on copper, Composites 228 (2022) 109427.

M.E. Belghiti , Y. El Oudadi , S. Echihi , A. Elmelouky , H. Outada ,Y. Karzazi , M. Bakasse , C. Jama , F. Bentiss , A. Dafali, Anticorrosive properties of two 3,5-dissubstitud-4-amino-1,2,4-triazole derivatives on copper in hydrochloric acid environment: Ac impedance, thermodynamic and computational investigations, Surfaces and Interfaces 21 (2020) 100692.

M. Belhadi, M. Oubahou, I. Hammoudan, A. Chraka, M. Chafi, S. Tighadouini, A comprehensive assessment of carbon steel corrosion inhibition by 1,10-phenanthroline in the acidic environment: insights from experimental and computational studies, Environmental Science and Pollution Research (2023).



07-08-2023 — Updated on 07-08-2023

How to Cite

El Harrari, S., Salim, A., Takky, D., & Naimi, Y. (2023). Corrosion inhibition effect of expired ibuprofen drug on copper in sulfuric acid solution: Original scientific paper. Journal of Electrochemical Science and Engineering, 13(6), 1005–1013.