A sensitive Cu(salophen) modified screen-printed electrode for simultaneous determination of dopamine and uric acid

Original scientific paper


  • Hadi Beitollahi School of Medicine, Bam University of Medical Sciences, Bam, Iran and Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran https://orcid.org/0000-0002-0669-5216
  • Somayeh Tajik Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran https://orcid.org/0000-0002-1151-5515
  • Mohammad Reza Aflatoonian Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
  • Asghar Makarem Department of Rehabmanagement, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran




Dopamine, uric acid, screen printed electrode, voltammetry, chemically modified electrodes, real sample analysis
Graphical Abstract


This research applied a nanostructured electrochemical sensor with a screen-printed electrode (SPE) for examining the dopamine (DA) electrocatalytic oxidation when uric acid (UA) was present. Cu(salophen) nanostructured modified SPE (Cu(salophen)/SPE) was employed to investigate the electrochemical behavior of DA. At optimal pH (pH 7.0), oxidation of DA at the modified electrode takes place at a potential around 100 mV less positive than at the unmodified SPE. Chronoamperometry was used to determine the diffusion coefficient of DA (D = 1.96×10-5 cm2 s-1). Differential pulse voltammetry (DPV) showed linear response in the range between 0.2-450.0 μM for DA. The limit of detection (LOD) of DA was computed to be 0.05 μM. Moreover, Cu(salophen)/SPE was employed for determining DA in the presence of UA using DPV. The DPV results showed that at the modified electrode, two well-separated oxidation peaks of DA and UA could be obtained at potentials of 180 and 325 mV, respectively. This separation forms the basis for the co-detection of these two materials on the surface of Cu(salophen)/SPE. This sensor was then employed to determine DA and UA in real specimens.


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How to Cite

Beitollahi, H., Tajik, S., Aflatoonian, M. R., & Makarem, A. . (2022). A sensitive Cu(salophen) modified screen-printed electrode for simultaneous determination of dopamine and uric acid: Original scientific paper. Journal of Electrochemical Science and Engineering, 12(1), 199–208. https://doi.org/10.5599/jese.1231



Electrochemical Science

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