ADMET and DMPK

Vol 4, No 2 (2016)

Changing trends in use of hepatocytes and microsomes for evaluating metabolism studies in drug discovery

Guest editor: Abdul Naveed Shaik

Table of Contents

Editorial

Changing trends in use of hepatocytes and microsomes for evaluating metabolism studies in drug discovery PDF
Abdul Naveed Shaik 60-61

Original Scientific Articles

Pharmacogenetic profiling and metabolic activity of human embryonic stem cell derived hepatocytes: focus on CYP450-mediated oxidation PDF
Jenna L. Voellinger, Edward J. Kelly 62-83
Metabolism of six CYP probe substrates in fetal hepatocytes PDF
Abdul Naveed Shaik, Sandeep Kumar Vishwakarma, Aleem A Khan 84-90
Calendula officinalis L. (Asteraceae) possess antioxidant properties on Fe2+-initiated peroxidation of rat brain microsomes PDF
Alejandro Palacios, Javier Barberón, Patricio Leaden, Pedro Zeinsteger 91-97
Defining desirable natural product derived anticancer drug space: optimization of molecular physicochemical properties and ADMET attributes PDF
Deepika Singh 98-113

Opinions

Is there a paradigm shift in use of microsomes and hepatocytes in drug discovery and development? PDF
Sumit Basu, Abdul Naveed Shaik 114-116

White papers

Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality PDF
Alex Avdeef, Elisabet Fuguet, Antonio Llinàs, Clara Ràfols, Elisabeth Bosch, Gergely Völgyi, Tatjana Verbić, Elena Boldyreva, Krisztina Takács-Novák 117-178

Education

Explore postgraduate biomedical engineering course integration between medical signal processing and drug development: example for drug development in brain disease PDF
Yin Tian, Li Yang, Zhongyan Wang, Huiling Zhang, Wei Xu, Shuxing Zheng, Haying Zhang, Dechun Zhao 179-181


ISSN 1848-7718