ADMET and DMPK  

Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development

Abdul Naveed Shaik, Ansar Ali Khan

Abstract


Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic or physiology based mathematical modeling technique which integrates the knowledge from both drug-based properties including physiochemical and biopharmaceutical properties and system based or physiological properties to generate a model for predicting the absorption, distribution, metabolism and excretion (ADME) properties of a drug as well as pharmacokinetic behavior of a drug in preclinical species and humans.


Keywords


PBPK, Drug Development, Model based drug development

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DOI: http://dx.doi.org/10.5599/admet.667

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ISSN 1848-7718