ADMET and DMPK  

Spectroscopic examination and release of microencapsulated oregano essential oil

Ioannis Partheniadis, Panagiota Karakasidou, Souzan Vergkizi, Ioannis Nikolakakis

Abstract


Oregano essential oil (EO) of Greek origin with high carvacrol content (86.84 %) was encapsulated by spray drying using Arabic gum, modified starch and maltodextrin (75:12.5:12.5) as wall materials. The spray-dried product (EOSD) consisted of roundish particles with narrow size distribution. FT-IR and Raman spectroscopy identified the EO in EOSD, with Raman spectra showing more distinct peaks and a small shift of the peak at 1260 cm-1 (assigned to the stretching vibration of the bond of C-O of the phenol), implying only minor chemical interaction with the wall materials. Release of the EO from EOSD was described by the Hixson-Crowell equation (R2=0.986) with apparent diffusion coefficient 8.3x10-10 m2/s. These findings indicate that microencapsulation by spray drying did not affect the quality of the oregano EO and provided relatively fast and complete release.


Keywords


oregano essential oil; microencapsulation; spray drying; FT-IR; Raman spectroscopy, in vitro release

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DOI: http://dx.doi.org/10.5599/admet.5.4.426

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ISSN 1848-7718