ADMET and DMPK  

Biomembrane mimics and their roles in anti-bacterial drug discovery

Xiaohui Hu, Kin Tam

Abstract


Cell membrane is at the frontline of the battle between pathogenic microbe and host. A thorough understanding of bacterial membrane is fundamental to tackle infection disease. Membrane mimetic provides a powerful tool for mechanistic interrogation of drug-membrane interaction. Herein, we summarized major features of bacterial and mammalian cell in context of antibacterial therapy. Much details were given to model membranes and their application in mechanistic studies. Current challenge in antibacterial therapy and perspective of membrane mimics in antibacterial drug discovery were also provided.

Keywords


Drug-membrane interaction; mode of action; liposome; supported lipid bilayer; resistance

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DOI: http://dx.doi.org/10.5599/admet.5.1.375

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ISSN 1848-7718