Special issue: Applications of biophysical techniques in drug discovery and development

Guest editor: Tatjana Verbić

Drug discovery and development in many pharmaceutical companies and academic laboratories have benefited from the rapid advancements in biophysical experimental methods over the last two decades. Techniques such as mass spectrometry, multidimensional nuclear magnetic resonance spectroscopy, image processing, X-ray diffraction, electron microscopy, atomic force microscopy, fluorescence spectroscopy, dynamic light scattering, surface plasmon resonance spectroscopy, differential scanning calorimetry and isothermal titration calorimetry are now routinely used in many key stages of the drug discovery and development. The demand for more automated and higher-throughput versions of instrumentation continues to grow.


With such advancement in instrumentation, great improvements in the speed, sensitivity and the range of possible biophysical measurements have been reached. High-resolution mechanistic, kinetic, thermodynamic and structural information on drug-target interactions are now available. In particular, biophysical measurements are useful in supporting compound progression, mechanistic understanding of the drug-receptor binding, validating potency data from biochemical and cellular assays in the discovery phases and quality control of the investigational drug, including the evaluations of drug release and stability, in the development phases.


This special issue will provide an overview of the current status and new achievements in using biophysical techniques in drug discovery and development. Novel research and challenges encountered will be discussed. Review, Opinion, Case studies and Commentary articles will also be welcome.


The deadline for the manuscript submissions is the end of October 01, 2019.

ISSN 1848-7718