J. Electrochem. Sci. Eng.  

Voltammetric and amperometric sensors for determination of epinephrine: A short review (2013-2017)

Hadi Beitollahi, Mohadeseh Safaei, Somayeh Tajik


The present review focuses on voltammetric and amperometric methods applied for determination of epinephrine (EP) in last five years (2013-2017). Occurrence, role and biological importance of EP, as well as non-electrochemical methods for its assessment, are firstly reviewed. The electrochemical behavior of EP is then illustrated, followed by a description of the voltammetric and amperometric methods for EP content estimation in various media. Different methods for development of electrochemical sensors are reviewed, starting from unmodified electrodes to different composites incorporating carbon nanotubes, ionic liquids or various mediators. From this perspective, the interaction between functional groups of the sensor material and the analyte molecule is discussed, as it is essential for analytical characteristics obtained. The analytical performances of the voltammetric or amperometric chemical and biochemical sensors (linear range of analytical response, sensitivity, precision, stability, response time, etc.) are highlighted. Numerous applications of EP electrochemical sensors in fields like pharmaceutical or clinical analysis where EP represents a key analyte, are also presented.


Epinephrine; electrooxidation; voltammetry: amperometry

Full Text:

PDF (952 kB)


W. Ge Yun, Chinese Journal of Chemistry 23 (2005) 297-302.

M. Mazloum Ardakani, H. Beitollahi, M. A. Sheikh Mohseni, A. Benvidi, H. Naeimi, M. Nejati-Barzoki, N. Taghavinia, ‎ Colloids and Surfaces B: Biointerfaces 76 (2010) 82-87.

F. Ni, Y.Wang, D. Zhang, M. Li, Electroanalysis 22 (2010) 1130-1135.

J. X. Qiao, H. Q. Luo, N. B. Li, Colloids and Surfaces B: Biointerfaces 62 (2008) 31-35.

W. Ren, H. Q. Luo, N. B. Li, Sensors 6 (2006) 80-89.

T. Łuczak, Electroanalysis 21 (2009) 2557-2562.

X. H Zhang, Sh. F. Wang, Analytical letters 35 (2002) 995-1006.

A. A. Ensafi, M. Taei, T. Khayamian, Colloids and Surfaces B: Biointerfaces 79 (2010) 480-487.

M. Taei, M. Jamshidi, Journal of Solid State Electrochemistry 18 (2014) 673-683.

S. Y. Ly, Analytical Letters 45 (2012) 1197-1203.

M. Taei, H. Hadadzadeh, F. Hasanpour, N. Tavakkoli, M. Hadadi Dolatabadi, Ionics 21 (2015) 3267-3278.

N. B. Li, L. M. Niu, H. Q. Luo, Microchimica Acta 153 (2006) 37-44.

M. Mazloum-Ardakani, H. Beitollahi, M. K. Amini, B. F. Mirjalili, F. Mirkhalaf, Journal of Electroanalytical chemistry 651 (2011) 243-249.

Y. X. Sun, S. Fu Wang, X. H. Zhang, Y. F. Huang, Sensors and Actuators B: Chemical 113 (2006) 156-161.

H. Beitollahi, H. Karimi-Maleh, H. Khabazzadeh, Analytical Chemistry 80 (2008) 9848-9851.

H. Beitollahi, M. Mazloum Ardakani, B. Ganjipour, H. Naeimi, Biosensors and Bioelectronics 24 (2008) 362-368.

T. Tavana, M. A. Khalilzadeh, H. Karimi-Maleh, A. A. Ensafi, H. Beitollahi, D. Zareyee, Journal of Molecular Liquids 168 (2012) 69-74.

H. Beitollahi, I. Sheikhshoaie, Analytical Methods 3 (2011) 1810-1814.

M. Mazloum-Ardakani, H. Beitollahi, M. K. Amini, F. Mirkhalaf, M. Abdollahi-Alibeik, Analytical Methods 3 (2011) 673-677.

H. Mahmoudi Moghaddam, H. Beitollahi, S. Tajik, H. Soltani, Electroanalysis 27 (2015) 2620-2628.

F. Wang, Y. Xu, L. Wang, K. Lu, B. Ye, Journal of Solid State Electrochemistry 16 (2012) 2127-2133.

W. Ma, D. M. Sun, Chinese Journal of Analytical Chemistry 35 (2007): 66-70.

S. Shahrokhian, R. S. Saberi, Electrochimica Acta 57 (2011) 132-138.

F. Cui, X. Zhang, Journal of Electroanalytical Chemistry 669 (2012) 35-41.

M. A. Fotopoulou, P. C. Ioannou, Analytica Chimica Acta 462 (2002) 179-185.

S. Shelkovnikov, H. C. Gonick, Life sciences 75 (2004) 2765-2773.

V. Carrera, E. Sabater, E. Vilanova, M. A. Sogorb, Journal of Chromatography B 847 (2007) 88-94.

X. Zhu, P. N. Shaw, D. A. Barrett, Analytica Chimica Acta 478 (2003) 259.

F. DP. Ferreira, L. IB Silva, A. C. Freitas, T. AP Rocha-Santos, A. C. Duarte, Journal of Chromatography A 1216 (2009) 7049-7054.

L. IB Silva, F. DP. Ferreira, A. C. Freitas, T. AP. Rocha-Santos, A. C. Duarte, Talanta 80 (2009) 853-857.

L. Zhang, S. Qv, Z. Wang, J. Cheng, Journal of Chromatography B 792 (2003) 381-385.

Sh. Wei, G. Song, J .M. Lin, Journal of Chromatography A 1098 (2005) 166-171.

E. M. Garrido, J. LFC. Lima, C. Delerue-Matos, Journal of Pharmaceutical and Biomedical Analysis 15 (1997) 845-849.

J. J. Willemsen, H. A. Ross, M. C. Jacobs, J. W. Lenders, T. H. Thien, L. M. Swinkels, T. J. Benraad, Clinical Chemistry 41 (1995) 1455-1460.

Y. Su, J. Wang, G. Chen, Talanta 65 (2005) 531-536.

J. Michałowski, P. Hałaburda, Talanta 55 (2001) 1165-1171.

M. H. Sorouraddin, J. L. Manzoori, E. Kargarzadeh, A. M. Haji Shabani, Journal of Pharmaceutical and Biomedical Analysis 18 (1998) 877-881.

M. Zhu, X. Huang, J. Li, H. Shen, Analytica Chimica Acta 357 (1997) 261-267.

X. Ma, M. Chao, Z. Wang. Analytical Method 4 (2012) 1687-1692.

X. Ma, M. Chen, X. Li, A. Purushothaman, F. Li, International Journal of Electrochemical Science 7 (2012) 991-1000.

Y. Zhang, W. Ren, Sh. Zhang, International Journal of Electrochemical Science 8 (2013) 6839-6844.

H. Beitollahi, S. Nekooei, M. Torkzadeh-Mahani, Talanta 188 (2018) 701-707.

H. Beitollahi, S. Ghofrani Ivari, M. Torkzadeh-Mahani, Biosensors Bioelectronics 110 (2018) 97-102.

J. Li, E. Shangguan, D. Guo, F. Gao, Q. Li, X. Z. Yuan, H. Wang, Electrochimica Acta 186 (2015) 209-215.

Z. Jemelkova, J. Barek, J. Zima, Analytical Letters 43 (2010) 1367-1376.

H. Kang, Y. Jin, Q. Han, Analytical Letters 47 (2014) 1552-1563.

Z. Xiu-Hua, Sh. F. Wang, Analytical Letters 35 (2013) 995-1006.

M. A. Yazdely, M. A. Taher, S. Tajik, Analytical & Bioanalytical Electrochemistry 5 (2013) 517-522.

S. Shankar, B. E. Kumara Swamy, International Journal of Electrochemical Science 9 (2014) 1321-1339.

M. Jahanbakhshi, Materials Science and Engineering C 70 (2017) 544-551.

B. N. Chendrashekar, B. E. Kumara Swamy, K. J. Gururaj, C. Cheng, Journal of Molecular Liquids 231 (2017) 379-385.

M. D. Tezerjani, A. Benvidi, A. Dehghani Firouzabadi, M. Mazloum-Ardakani, A. Akbari, Measurement 101 (2017) 183-189.

M. Taei, F. Hasanpour, N. Tavakkoli, M. Bahrameian, Journal of Molecular Liquids 211 (2015) 353-362.

Li. I. Hongying, W. A. N. G. Xueliang, Electrochemistry 83 (2015) 434-439.

Ç. Koçak, Z. Dursun, Journal of Electroanalytical Chemistry 694 (2013) 94-103.

B. Devadas, M. Rajkumar, Sh. M. Chen, Colloids and Surfaces B: Biointerfaces 116 (2014) 674-680.

M. Taei, M. Jamshidi, Journal of Solid State Electrochemistry 18 (2014) 673-683.

W. Ma, X. Yao, D. Sun, Asian Journal of Chemistry 25 (2013) 6625-6632.

H. Li, D. Sun, Asian Journal of Chemistry 27 (2015) 2539-2542.

B. Mekassa, M. Tessema, B. S. Chandravanshi, P. GL Baker, F. N. Muya. Journal of Electroanalytical Chemistry 807 (2017) 145-153.

S. da, L. Vieira, C. Bezerra Lopes, W. Ceciliano d. Silva, Y. Galdino d. Paiva, F. de Assis dos Santos Silva, P. Rodrigues Lima, L. Tatsuo Kubota, M. Oliveira Fonseca Goulart. Microchemical Journal 133 (2017) 460-467.

H. Mao, H. Zhang, W. Jiang, J. Liang, Y. Sun, Y. Zhang, Q. Wu, G. Zhang, X. M. Song. Materials Science and Engineering: C 75 (2017) 495-502.

I. M. Apetrei, C. Apetrei, International Journal of Nanomedicine 8 (2013) 4391-4399.

F. Valentini, E. Ciambella, V. Conte, L. Sabatini, N. Ditaranto, F. Cataldo, G. Palleschi, Biosensor and Bioelectronics 59 (2014) 94-106.

M. E. Ghica, Ch. M. A. Brett, Analytical Letters 46 (2013) 1379-1393.

M. Mazloum-Ardakani, F. Sabbaghian, B. F. Mirjalili, M. A. Sheikh-Mohseni, Analytical and Bioanalytical Electrochemistry 6 (2014) 106-119.

Y. Wu, X. Feng, Sh. Zhou, H. Shi, H. Wu, Sh. Zhao, W. Song, Microchimica Acta 180 (2013) 1325-1332.

X. Wang, J. Li, Z. Yu, International Journal of Electrochemical Science 10 (2015) 93-101.

H. Rajabi, M. Noroozifar, M. Khorasani-Motlagh, Analytical & Bioanalytical Electrochemistry 8 (2016) 522-531.

A. Babaei, E. Rezaei, M. Sohrabi, O. Karbalaei Hasani, Analytical & Bioanalytical Electrochemistry 7 (2015) 302-311.

P. Pradhan, R. J. Mascarenhas, T. Thomas, I. N. N. Namboothiri, O. J. D’Souza, Z. Mekhalif, Journal of Electroanalytical Chemistry 732 (2014) 30-37.

T. Thomas, R. J. Mascarenhas, O. J. D'Souza, S. Detriche, Z. Mekhalif, P. Martis, Talanta 125 (2014) 352-360.

F. Figueiredo, L.CS. Tiago, A. Silva, F. C. Vicentini, O. Fatibello-Filho, Analyst 139 (2014) 2842-2849.

K. K Reddy, M. Satyanarayana, K. Yugender Goud, K. Vengatajalabathy Gobi, Materials Science and Engineering C 79 (2017) 93-99.

R. Sadeghi, H. Karimi-Maleh, A. Bahari, M. Taghavi. Physics and Chemistry of Liquids 51 (2013) 704-714.

A. Babaei, M. Afrasiabi, Gh. Azimi, Analytical Methods 7 (2015) 2469-2478.

L. Zou, Y. Li, Sh. Cao, B. Ye, Talanta 117 (2013) 333-337.

I. E. Silai, I. C. Fort, D. Casoni, G. L. Turdean, Revue Roumane de Chimie 60 (2015) 689-696.

M. Mazloum-Ardakani, A. Dehghani-Firouzabadi, N. Rajabzade, M. A. Sheikh-Mohseni, A. Benvidi, M. Abdollahi-Alibeik, Journal of the Iranian Chemical Society 10 (2013) 1-5.

B. Jin, H. Zhang. Analytical Letters 35 (2014) 1907-1918.

A. S.Razaviansra, S. M. Ghoreishi, A. S. Esmaeily, M. Behpour, L. MA Monzon, J. M. D. Coey, Microchimica Acta 181 (2014) 1947-1955.

Q. Yang, Y. Zhao, J. Bai, L. Wu, H.M. Zhang, L. Qu, Analytical Methods 7 (2015) 10394-10402.

M. F. Chen, X. Y. Ma, Russian Journal of Applied Chemistry 87 (2014) 200-206.

H. Xu, X. Wang, R. Chen, Z. Yu, Chemical Research in Chinese Universities 30 (2014) 205-210.

Ch. H. Mak, C. Liao, Y. Fu, M. Zhang, Ch. Y. Tang, Y. H. Tsang, H. LW Chan, F. Yan, Journal of Materials Chemistry C 3 (2015) 6532-6538.

H. Beitollahi, M. A. Taher, A. Hosseini, Measurement 51 (2014) 156-163.

Kang, Hongzhe, Yan Jin, Qian Han, Analytical Letters 47 (2014) 1552-1563.

G. Ibáñez-Redín, D. Wilson, D. Gonçalves, O. N. Oliveira, Journal of colloid and interface science (2017). https://doi.org/10.1016/j.jcis.2017.12.085

V. K. Gupta, H. Mahmoody, F. Karimi, Sh. Agarwal, M. Abbasghorbani. International Journal of Electrochemical Science 12 (2017) 248-257.

A. C. Anithaa, K. Asokan, C. Sekar. Electrochimica Acta 237 (2017) 44-53.

T. P Tsele, A. S. Adekunle, E. F. Omolola, E. E. Eno, Electrochimica Acta 243 (2017) 331-348.

DOI: http://dx.doi.org/10.5599/jese.569

jESE : : Open Access Journal  :  : ISSN 1847-9286